Results 111 to 120 of about 5,227 (304)
Interpreting Pictures: Bridging the Literacy Gap with Graphic Novels
, 2021 Graphic novels have significantly grown in popularity over the past decade, increasing their impact on modern literary culture. In an effort to engage reluctant readers in literacy education, teachers have utilized graphic novels in their classroom as a ...
Cornelius, Daniela
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2011 It is becoming increasing important that teachers educate students about social studies in such a way so that students are interested and motivated by what they read.
Johannessen, Lindsey
core
LGBTQ+ Webcomics and Graphic Novels
, 2020 An overview of how the uniquely visual and widely accessible formats of YA graphic novels, comics, and webcomics have broadened LGBTQ+ visibility and representation.
Thomas, Ridley, Marcoux, Nicole
core
Graphic novels: enticing teenagers into the library [PDF]
, 2011 This thesis investigates the inclusion of graphic novels in library collections and whether the format encourages teenagers to use libraries and read in their free time.
Snowball, Clare
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Revista Lusófona de Estudos CulturaisGender-based violence, defined as any act of violence perpetrated due to the victim’s gender (Boyle, 2019), is a pervasive phenomenon with substantial socio-economic costs.
Nicoletta Mandolini, Cristina Álvares
doaj +1 more source
Engaging English Language Learners Through the Use of Graphic Novels
, 2020 This paper will examine the benefits of using graphic novels in the classroom to engage English Language Learners. Graphic novels have carried a negative stigma since the publishing of “Seduction of the Innocent” by Frederick Wertham which claimed to ...
Ortega, Maribel
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source