Results 111 to 120 of about 48,970 (328)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Steiner graphical t -wise balanced designs of type n \u3c sup\u3e r \u3c/sup\u3e
, 2000 In this article we completely determines all proper Steiner graphical t-wise balanced designs whose automorphisms contain the group SnwrSr (wreath product) acting on the set of n2r2 edges of the complete r-partite graph, Kn,n,...,n.
Kreher, Donald L., Olsen, Cheryl L.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Combinatorial Optimization of Graphical User Interface Designs [PDF]
, 2020 Antti Oulasvirta +4 more
openalex +1 more source
Quantitative literacy practices in civil engineering study: designs for teaching and learning
, 2016 : Higher education needs to produce increasing numbers of good quality graduates. Included herein is the need for graduates that can engage in high level quantitative literacy practices, which requires designs for learning that understand how texts are ...
Simpson, Zach, Prince, Robert
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, 2006 We introduce a theory of hypergraphical t-designs. We show the existence of these designs and prove a finiteness theorem on these designs for infinitely many parameter sets. We also give effective bounds on the number of points in these cases.
Ngo Dac Tuan, Tuan, Ngo Dac
core +1 more source
Graphical Smooth Switching Control Method of Four-Switch Buck-Boost Converter in Fuel Cell Systems
IEEE AccessThis paper proposes a graphical smooth switching control method for a four-switch Buck-Boost (FSBB) converter in fuel cell systems. Traditional FSBB converters can reduce average inductance current in multi-mode operations.
Hongwei Feng +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2005 We review the practice of experimental design in the environmental economics literature concerned with choice experiments. We then contrast this with advances in the field of experimental design and present a comparison of statistical efficiency across ...
RICCARDO SCARPA +2 more
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