Results 131 to 140 of about 48,970 (328)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Graphical technique for comparing designs for random models
Methods for comparing designs for a random (or mixed) linear model have focused primarily on criteria based on single-valued functions. In general, these functions are difficult to use, because of their complex forms, in addition to their dependence on ...
Juneyoung Lee, Andre Khuri
core +1 more source
ISML: an interface specification meta-language
, 2003 In this paper we present an abstract metaphor model situated within a model-based user interface framework. The inclusion of metaphors in graphical user interfaces is a well established, but mostly craft-based strategy to design.
Simon Crowle +3 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Graphical predetermination of optimal machine designs by iso-performance configuration modeling
, 2020 Stéphane Vivier
openalex +2 more sources
Visual Inference and Graphical Representation in Regression Discontinuity Designs
, 2020 Despite the widespread use of graphs in empirical research, little is known about readers’ ability to process the statistical information they are meant to convey (“visual inference”).
Matsudaira, Jordan +4 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Graphical Models for Quasi-experimental Designs
, 2015 Peter M. Steiner +3 more
openalex +2 more sources
, 2018 We use semidefinite programming (SDP) to find a variety of optimal designs for multi-response linear models with multiple factors, and for the first time, extend the methodology to find optimal designs for multi-response nonlinear models and generalized ...
Wong, Weng Kee, Zhou, Julie
core +1 more source