Results 91 to 100 of about 1,088,373 (345)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Aspects of graphic art expression in the context of the development of fine arts in Bessarabia during the period of reintegration of the region into the Kingdom of Romania (1918–1940) [PDF]

Dialogica: Revistă de Studii Culturale și Literatură
Between 1918 and 1940, the modern fine arts in the region demonstrated the predominance of Romanian and Western European cultural-artistic influences over Eastern ones.
Elena MUSTEAȚĂ
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

HISTORICAL GRAPHICS [PDF]

Science, 1909
  +8 more sources

An optimization method for hemi-diaphragm measurement of dynamic chest X-ray radiography during respiration based on graphics and diaphragm motion consistency criterion

Frontiers in Physiology
IntroductionExisting technologies are at risk of abnormal hemi-diaphragm measurement due to their abnormal morphology caused by lung field deformation during quiet breathing (free respiration or respiratory) interventions in dynamic chest radiography ...
Yingjian Yang, Jie Zheng, Peng Guo, Tianqi Wu, Qi Gao, Yong Li, Chengcheng Liu, Yang Liu, Yingwei Guo, Huai Chen   +9 more
doaj   +1 more source

Spacecraft Reaction Wheels [PDF]

, 2011
This activity is designed to introduce the engineering aspects of precision pointing of spacecraft.

core  

Improved Parallel Rabin-Karp Algorithm Using Compute Unified Device Architecture

, 2018
String matching algorithms are among one of the most widely used algorithms in computer science. Traditional string matching algorithms efficiency of underlaying string matching algorithm will greatly increase the efficiency of any application. In recent
D Xu, DE Knuth, M Gongora-Blandon, N Singla, RM Karp, RS Boyer, RS Chillar   +6 more
core   +1 more source

EXAMPLES OF INNOVATIVE METHODS OF TEACHING COMPUTER GRAPHICS SUBJECTS (RESULTS AND DISCUSSION)

, 2023
Nazarova Shakhnoza Shokirovna, Information Technologies In Technical Systems"   +1 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source