Results 91 to 100 of about 3,335,840 (376)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

open access: yesMolecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban   +12 more
wiley   +1 more source

Використання вільно поширюваних програмних засобів при вивченні комп’ютерної графіки та анімації на уроках інформатики в Технічному ліцеї [PDF]

open access: yes, 2015
The Purpose of the research is review the free software that can be used in the study of topics of computer graphics and animation on informatics lessons. The Object is a vector graphics editor Inkscape, bitmap Gimp, vector animation Synfig Studio.
Кузьменко, Алла Володимирівна
core  

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga   +8 more
wiley   +1 more source

GENIE: a software package for gene-gene interaction analysis in genetic association studies using multiple GPU or CPU cores

open access: yesBMC Research Notes, 2011
Background Gene-gene interaction in genetic association studies is computationally intensive when a large number of SNPs are involved. Most of the latest Central Processing Units (CPUs) have multiple cores, whereas Graphics Processing Units (GPUs) also ...
Wang Kai   +2 more
doaj   +1 more source

Realtime multi-plot graphics system [PDF]

open access: yes
The increased complexity of test operations and customer requirements at Langley Research Center's National Transonic Facility (NTF) surpassed the capabilities of the initial realtime graphics system.
Shipkowski, Michael S.
core   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

open access: yesMolecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová   +14 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Interactive computer graphics system for structural sizing and analysis of aircraft structures [PDF]

open access: yes
A computerized system for preliminary sizing and analysis of aircraft wing and fuselage structures was described. The system is based upon repeated application of analytical program modules, which are interactively interfaced and sequence-controlled ...
Bendavid, D.   +3 more
core   +1 more source

Building an interactive 3D animation system [PDF]

open access: yes, 1993
The continued improvement and proliferation of graphics hardware for workstations and personal computers has brought increasing prominence to a newer style of software application program. This style relies on fast, high quality graphics displays coupled
Balaguer, Jean-Francis   +3 more
core  

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