Results 41 to 50 of about 576,949 (348)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

EVALUTION OF LEARNING FACILITIES SUPPORTING CREATIVE PRODUCTS AND ENTREPRENEURSHIP IN MODELING DESIGN AND BUILDING INFORMATION EXPERTISE COMPETENCY

Jurnal Pensil, 2023
This study aims to gain a general understanding of the state of educational infrastructure and learning facilities for creative and entrepreneurial products, as well as a general understanding of the degree of standard compliance and the appropriateness
Wisnu Rachmad Pribadi, Ikhwanuddin, Abdul Malik, Rudi Nur Syamsudin, M. Arif Faisal   +4 more
doaj   +1 more source

Proprietary software tools as learning aids [PDF]

, 2007
Proprietary software tools, though not designed for educational use, have considerable educational potential. This paper describes, as case studies, the use of proprietary graphics- and audio-editing tools in two distance-taught courses produced by the ...
Jones, Allan
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research on Standardized Testing Processes and Methods of Graphics Measurement Functions of Medical Device Software

Zhongguo yiliao qixie zazhi
With the widespread application of medical device software in clinical diagnosis and treatment, the accuracy and reliability of graphics measurement functions, which are core modules of medical device software, directly impact the quality of medical ...
Zhongsheng LIU, Yinjie LI
doaj   +1 more source

«Life» in Tensor: Implementing Cellular Automata on Graphics Adapters

Труды Института системного программирования РАН, 2019
This paper presents an approach to the description of cellular automata using tensors. This approach allows to attract various frameworks for organizing scientific calculations on high-performance graphics adapter processors, that is, to automatically ...
Natalia Andreevna Shalyapina, Maxim Leolidovitch Gromov   +1 more
doaj   +1 more source

Multivisual Animation Character 3D Model Design Method Based on VR Technology

Complexity, 2021
For VR systems, one of its core parts is to present people with a real and immersive 3D simulation environment. This paper uses real-time computer graphics technology, three-dimensional modeling technology, and binocular stereo vision technology to study
Leiming Li, Wenyao Zhu, Hongwei Hu
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Design of Dot-matrix Drawing Software Used in Mine LED Electronic Display Board

Gong-kuang zidonghua, 2012
For problems of inaccurate drawing and poor visibility of mine LED electronic display board using vector technical to draw graphics, the paper proposed a design scheme of dot-matrix drawing software which can be applied in different types of electronic ...
DING Rui-qi, HE Yao-yi, WANG Yong, ZHANG Wei-guo, YAN Zhao-zhen, SU Lin   +5 more
doaj  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source