Results 41 to 50 of about 3,335,840 (376)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Perprof-py: A Python Package for Performance Profile of Mathematical Optimization Software

Journal of Open Research Software, 2016
A very important area of research in the field of Mathematical Optimization is the benchmarking of optimization packages to compare solvers. During benchmarking, one usually collects a large amount of information like CPU time, number of functions ...
Abel Soares Siqueira, Raniere Gaia Costa da Silva, Luiz-Rafael Santos   +2 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Automatic Modification of Steel House Drawings by Finite Element Software for Coal Yard in Power Plant

发电技术, 2018
In order to reduce environmental effect by open coal yard in power plant, coal yard in power plants is required to be transformed into a closed space. The closed transformation of the coal yard adopts a large steel structure.
Zhengxin LI, Liangliang DING, Yinping HAO, Dongmei DU   +3 more
doaj   +1 more source

التعليم الإلکترونى ودوره فى فن الجرافيک بکليات الفنون الجميلة لمواکبة تکنولوجيا العصر [PDF]

Journal of Distance Learning and Open Learning, 2014
Search provides a vision of the importance of e-learning and its objectives and its features and benefits , and their strategies as well as Arab and international experiences that have to go to be applied in different educational environments experience ...
أحمد أحمد
doaj   +1 more source

Software and graphical user interfaces [PDF]

, 2020
This Handbook provides a scholarly and comprehensive account of the multiple converging challenges that digital technologies present for intellectual property (IP) rights, from the perspectives of international, EU and US law.
openaire   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Approximate Bayesian Image Interpretation using Generative Probabilistic Graphics Programs [PDF]

, 2013
The idea of computer vision as the Bayesian inverse problem to computer graphics has a long history and an appealing elegance, but it has proved difficult to directly implement.
Kulkarni, Tejas D., Mansinghka, Vikash K., Perov, Yura N., Tenenbaum, Joshua B.   +3 more
core   +4 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

CREATING AN INFORMATIONAL WEBSITE FOR PHYSICS ACADEMIC COURSE: WEB DESIGN SPECIFICS

Інформаційні технології і засоби навчання, 2017
The article is devoted to the analysis of means and methods of creating an educational informational website for the Physics academic course. The stages of technical task creation, design of the main and typical pages of the website, layout, programming,
Іryna A. Slipukhina, Taras V. Gedenach, Vyacheslav V. Olkhovyk   +2 more
doaj