Results 31 to 40 of about 1,904,993 (351)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Visiting the Prophet at His Grave: Discussions about the Religious Topography of Madina

Religions
Theological discussions about visits to the Prophet’s grave in Madina are the focus of this paper. The relevant question in this context relates to the idea of a postmortem life of the Prophet and its accessibility for believers after his death. The idea
Martin Kellner
doaj   +1 more source

The “grave covering” of St Demetrios between Byzantium and Rus [PDF]

, 2014
Much scholarly attention has focused on the role of St Demetrios in the maintenance of the civic identity and cultural independence of Thessalonika, the Byzantine Empire’s second city. Yet Thessalonika did not always win this struggle with Constantinople.
White, Monica
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Domain adaptation for sequence labeling using hidden Markov models [PDF]

, 2013
Most natural language processing systems based on machine learning are not robust to domain shift. For example, a state-of-the-art syntactic dependency parser trained on Wall Street Journal sentences has an absolute drop in performance of more than ten ...
Bach, Francis, Grave, Edouard, Obozinski, Guillaume   +2 more
core   +3 more sources

Modeling Graves’ Orbitopathy in Experimental Graves’ Disease [PDF]

Hormone and Metabolic Research, 2015
AbstractGraves’ orbitopathy (GO), also known as thyroid eye disease is an inflammatory disease of the orbital tissue of the eye that arises as a consequence of autoimmune thyroid disease. The central feature of the disease is the production of antibodies to the thyrotropin hormone receptor (TSHR) that modulate the function of the receptor leading to ...
Banga, J P, Moshkelgosha, S, Berchner-Pfannschmidt, Utta, Eckstein, Anja   +3 more
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

ОБ УСТРОЙСТВЕ ПЕРЕКРЫТИЙ В ПОДБОЙНЫХ МОГИЛАХ РИМСКОГО ВРЕМЕНИ НА НЕКРОПОЛЯХ БЛИЖАЙШЕЙ ОКРУГИ ХЕРСОНЕСА* [PDF]

Материалы по археологии и истории античного и средневекового Причерноморья
Представлены предварительные наблюдения по одному из малоизученных аспектов устройства погребальных сооружений римского времени Юго-Западного Крыма — способам перекрытия подбойных ниш.
Свиридов, А.Н.
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source