Results 31 to 40 of about 357,901 (301)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Visiting the Prophet at His Grave: Discussions about the Religious Topography of Madina

Religions
Theological discussions about visits to the Prophet’s grave in Madina are the focus of this paper. The relevant question in this context relates to the idea of a postmortem life of the Prophet and its accessibility for believers after his death. The idea
Martin Kellner
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

ОБ УСТРОЙСТВЕ ПЕРЕКРЫТИЙ В ПОДБОЙНЫХ МОГИЛАХ РИМСКОГО ВРЕМЕНИ НА НЕКРОПОЛЯХ БЛИЖАЙШЕЙ ОКРУГИ ХЕРСОНЕСА* [PDF]

Материалы по археологии и истории античного и средневекового Причерноморья
Представлены предварительные наблюдения по одному из малоизученных аспектов устройства погребальных сооружений римского времени Юго-Западного Крыма — способам перекрытия подбойных ниш.
Свиридов, А.Н.
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Vedic Agni and Scandinavian Fire Rituals: A Possible Connection

Current Swedish Archaeology, 2005
To use ethnographic analogies is not the same as picking up ready-made interpretations from one cultural context and importing them into another. On the contrary, analogies are a powerful and necessary tool for any archaeological interpretation.
Anders Kaliff
doaj   +1 more source

Kurgan, New Suggestions and Its Possible Role in Intercultural Interactions: the Northern Black Sea (Greater Olbia) Case

Anadolu Araştırmaları, 2022
Apart from some controversial ones, kurgans are a model of grave architecture frequently used by ancient Eurasian societies in the steppes, with the oldest-known examples of kurgans dating back to the third millennium BC.
Okan Sezer
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Un mormânt sarmatic descoperit la Călăraşi

Materiale și Cercetări Arheologice, 2012
The grave from Călăraşi was published in 1952 as an analogy for a tomb found in Moldavia, but it was followed neither by a discussion or a detailed description of the gravegoods, nor by photos or drawings.
Oța, L., Comșa, A.
doaj   +1 more source