Results 41 to 50 of about 357,901 (301)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
quam ... pro summis in utroque iure honoribus ... doctoralibus ... consequendis, solenni & publico eruditoruem examini submittit Eberhardus Grave, Hamburgensis. D. ... mens. Februarii, an M DC LVIIEnthält 20 ThesenDatum hs. ergänzt: D. 27.
Grave, Eberhard
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Modeling Graves’ Orbitopathy in Experimental Graves’ Disease [PDF]
Hormone and Metabolic Research, 2015 AbstractGraves’ orbitopathy (GO), also known as thyroid eye disease is an inflammatory disease of the orbital tissue of the eye that arises as a consequence of autoimmune thyroid disease. The central feature of the disease is the production of antibodies to the thyrotropin hormone receptor (TSHR) that modulate the function of the receptor leading to ...
Banga, J P +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FINIS: Objects of the End of Time, Afterlife Writing and Situation of Graves
European Journal of Life Writing, 2020 Focusing on Hogarth’s last graphic work, The Bathos, this essay examines the ways in which the vanitas themes it represents are bound up with events that occurred towards the end of the artist’s life.
Jane Wildgoose
doaj +1 more source
Diarrea grave en una lactante previamente sana: un reto diagnóstico [PDF]
, 2022 Pérez Salas S, García Vega M, García Barba S, Salmón Rodríguez N, González Granados LI, Salcedo Lobato E, et al. Diarrea grave en una lactante previamente sana: un reto diagnóstico. Rev Pediatr Aten Primaria.
Salcedo Lobato, Enrique +6 more
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source