Results 91 to 100 of about 64,440 (255)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Two Cases of Graves’ Disease Presenting with Unilateral Involvement of the Thyroid Gland

Endocrinology Research and Practice, 2007
Graves’ disease is an autoimmune disorder of the thyroid which is characterized by hyperthyroidism and frequently accompanying diffuse goiter. Thyroid scan reveals diffuse bilateral increased uptake of radioisotopes. Unilateral involvement of the thyroid
Gürcan Kısakol, Mehtap Çakır, Kağan Güngör, Mustafa Sait Gönen   +3 more
doaj   +2 more sources

Takotsubo Cardiomyopathy and Graves’ Disease

, 2016
While Graves’ disease has been a well-known clinical entity for some time, takotsubo cardiomyopathy (TTC) has become recognised as an acute heart failure syndrome only in recent years.
Rainer Zbinden, Damian Gruber
core   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

A higher incidence of cardiovascular complications in hyperthyroid patients with Graves’ disease in comparison to hyperthyroid patients with subacute thyroiditis

Zdravniški Vestnik
Background: Hyperthyroidism, as well as systemic inflammation, are associated with a higher incidence and complications of cardiovascular disease. Both in Graves’ disease and subacute thyroiditis, patients are hyperthyroid.
Ana Šešek, Simona Gaberšček, Katja Zaletel, Edvard Pirnat, Katica Bajuk Studen   +4 more
doaj   +1 more source

Family-Based Association Study of Cytotoxic T-Lymphocyte Antigen-4 with Susceptibility to Graves' Disease in Han Population of Taiwan

, 2011
Graves' disease (GD) is a common organ-specific autoimmune disorder inherited as a complex trait. Although there has not been consensus regarding the genuine susceptibility alleles, many population-based genetic studies showed association of the ...
CHEN, PEI-LUNG;FANN, CATHY SHENG-JIUAN;CHANG, CHIEN-CHING;WU, I-LIN;CHIU, WEI-YIH;LIN, CHIN- YU;YANG, WEI-SHIUNG;CHANG, TIEN-CHUN, 陳沛隆;范盛娟;張倩青;吳宜凌;邱偉益;林錦鈺;楊偉勛;張天鈞   +1 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Thyroid malignancies in patients with Graves' disease [PDF]

, 2016
Amaç: Graves' hastalığı otoimmün bir tiroid hastalığıdır. Eş zamanlı primer tiroid maligniteleri ile Graves' hastalığı birlikteliği, giderek artan bir sıklıkta bildirilmektedir.
Güçer, Hasan
core  

The immunogenetics of Graves' disease

, 1999
Graves' disease clusters in families, and higher concordance rates in monozygotic compared with dizygotic twins support a genetic basis to the disease.
Gough, SCL
core   +1 more source