Results 151 to 160 of about 5,085,125 (242)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Graves' disease and bone mineral density: a meta-analysis and UK Biobank. [PDF]

Front Endocrinol (Lausanne)
Wu M, Wang J, Lu Y, Yuan M, Ji J, Liang J, Cui J, Wang H, Xu H, Liu T, Shen Y, Fu F, Shi S, Shi Q, Shen L, Tang D, Yuan C, Wang Y.   +17 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Cytokines and drugs targeting cytokines in Graves' disease and thyroid eye disease. [PDF]

Front Immunol
Ferrari SM, Elia G, Ragusa F, Balestri E, Botrini C, Mazzi V, Baglini A, Rugani L, Del Carlo G, Rizzi R, Cimbalo B, Virili C, Baldini E, Varricchi G, Antonelli A, Fallahi P.   +15 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Psychological and Physiological Stress and the Onset and Course of Graves' Disease: A Systematic Review. [PDF]

Cureus
Nureldaim Ahmed SN, Alhajri AHM, Elfaki Omer EO, Elneel Rabah HA, Mohamed Abdalla SA, Hassan Khattab RA, Osman Ali EN, Bayonis EB.   +7 more
europepmc   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Recurrent Ventricular Fibrillation Associated With Graves' Disease: A Case Report. [PDF]

Case Rep Cardiol
Moon IT, Kim S, Park SH, Ki YJ, Chin JY.
europepmc   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

Advanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li, Yifei Cao, Jiaxin Lin, Huayong Yang, Hongzhao Zhou   +4 more
wiley   +1 more source

Unilateral Graves' Disease Developing During Treatment With Tirzepatide in a Patient With Diabetes: A Case Report. [PDF]

Case Rep Endocrinol
Deto Y, Hasegawa R, Ino S, Shibata S, Ohno K, Itoh T, Matsumoto T, Miki T.   +7 more
europepmc   +1 more source