Results 11 to 20 of about 280,401 (218)

Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes

Frontiers in Immunology, 2022
Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease.
Jingyi Zheng, Jingyi Zheng, Honghong Duan, Sufang You, Sufang You, Bo Liang, Yuping Chen, Yuping Chen, Huibin Huang   +8 more
doaj   +2 more sources

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Journal of Ophthalmology, 2020
Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population ...
Cetin Akpolat, Muhammed M. Kurt, Merve Yılmaz, Fikriye Ordulu, Ferhat Evliyaoglu   +4 more
doaj   +2 more sources

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition. [PDF]

Adv Sci (Weinh)
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Zhang Y, Wu E, Liu W, Zeng L, Ling N, Wang H, Li Z, Yao S, Pan T, Li X, Huang Y, Li X, Tu Y, Yan W, Wu J, Ye M, Wu W.   +16 more
europepmc   +2 more sources

Application of Multiparameter Quantitative Magnetic Resonance Imaging in the Evaluation of Graves' Ophthalmopathy

Journal of Magnetic Resonance Imaging, 2023
Assessment of the activity of Graves' ophthalmopathy (GO) is difficult. Existing methods need improvement.
Zhangfang Li, Yaosheng Luo, Xiaoting Feng, Qing Zhang, Qiang Zhong, Chanyan Weng, Zhi Chen, Jie Shen   +7 more
semanticscholar   +1 more source

Current insights of applying MRI in Graves’ ophthalmopathy

Frontiers in Endocrinology, 2022
Graves’ ophthalmopathy (GO) is an autoimmune disease related to Grave’s disease (GD). The therapeutic strategies for GO patients are based on precise assessment of the activity and severity of the disease.
C. Song, Yaosheng Luo, Gaofeng Yu, Haixiong Chen, Jie Shen   +4 more
semanticscholar   +1 more source

Emerging Insights Into the Role of Epigenetics and Gut Microbiome in the Pathogenesis of Graves’ Ophthalmopathy

Frontiers in Endocrinology, 2022
Graves’ Ophthalmopathy (GO) is an organ-specific autoimmune disease that is often characterized by infiltration of orbital tissues and is considered as the most common extra-thyroid manifestation of Graves’ disease (GD).
Yan Wang, Xiao-Min Ma, Xin Wang, Xin Sun, Ling Wang, Xin-Qi Li, Xiaoyang Liu, Hongyang Yu   +7 more
semanticscholar   +1 more source

Tear-derived exosomal biomarkers of Graves’ ophthalmopathy

Frontiers in Immunology, 2022
Graves’ ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves’ disease (GD), can lead to a significant decline in the quality of life in patients.
Tingting Shi, Ruxuan Zhao, Z. Xin, Z. Hou, Hua Wang, Rongrong Xie, Dong-mei Li, Jin-Kui Yang   +7 more
semanticscholar   +1 more source

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy

Biomedicines, 2021
Graves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. It is characterized initially by an inflammatory process, followed by tissue remodeling and fibrosis, leading to proptosis, exposure keratopathy, ocular ...
Tzu-Yu Hou, Shi-Bei Wu, H. Kau, Chieh-Chih Tsai   +3 more
semanticscholar   +1 more source

Cytokines as Targets of Novel Therapies for Graves’ Ophthalmopathy

Frontiers in Endocrinology, 2021
Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism.
P. Fallahi, S. Ferrari, G. Elia, F. Ragusa, S. Paparo, A. Patrizio, S. Camastra, M. Miccoli, G. Cavallini, S. Benvenga, A. Antonelli   +10 more
semanticscholar   +1 more source

The Role of Fibrogenesis and Extracellular Matrix Proteins in the Pathogenesis of Graves' Ophthalmopathy. [PDF]

Int J Mol Sci
Graves’ ophthalmopathy (GO), or thyroid eye disease (TED), is the most frequent extrathyroidal manifestation of Graves’ disease (GD). Inflammation and subsequent aberrant tissue remodeling with fibrosis are important pathogenesis. There are many proposed
Chiu HI, Wu SB, Tsai CC.
europepmc   +2 more sources