Results 61 to 70 of about 5,054 (133)

The thyroid, the eyes and the gut: a possible connection [PDF]

, 2017
Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per year in England.
Covelli, D., Ludgate, Marian Elizabeth
core   +2 more sources

Factors Influencing the Conversion of Ocular Myasthenia Gravis to Generalized Myasthenia Gravis: A Retrospective Cohort Study

Journal of Ophthalmology, Volume 2026, Issue 1, 2026.
Purpose The conversion rate of ocular myasthenia gravis (OMG) to generalized myasthenia gravis (GMG) lacks definitive predictors. Methods This retrospective cohort study analyzed data collected at Siriraj Hospital between January 2007 and December 2019 to identify factors influencing OMG generalization and the time to conversion. The records of 200 OMG
Wanicha Chuenkongkaew, Niphon Chirapapaisan, Pawimon Chatchutimakorn, Natthapon Rattanathamsakul, Manassawee Joradoln, Pawita Kongthanasomboon, Akarawit Eiamsamarng, Gábor Tóth   +7 more
wiley   +1 more source

Development and psychometric properties of the Thai Graves’ ophthalmopathy quality of life (GO-QOL) questionnaire

Journal of Patient-Reported Outcomes, 2019
Purpose To develop and assess the psychometric properties of the Thai version of the Graves’ Ophthalmopathy Quality of Life (GO-QOL) questionnaire. Background Graves’ ophthalmopathy (GO) is a chronic condition that causes negative self-image and impaired
Mingkwan Lumyongsatien, Benjama Keeratidamkerngsakul, Kanokrat Pornpanich, Sumalee Vangveeravong, Preamjit Saonanon, Damrong Wiwatwongwana, Pornchai Mahaisavariya, Orapan Aryasit, Krit Pongpirul   +8 more
doaj   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Glymphatic System Dysfunction in Thyroid‐Associated Ophthalmopathy: A Multimodal MRI Study

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
TAO patients exhibit impaired glymphatic function, with reduced DTI‐ALPS indices and gBOLD‐CSF coupling, but unchanged choroid plexus volume. These alterations correlate with neuropsychological symptoms and sleep disturbances. Restoring glymphatic activity may offer a therapeutic approach to enhance patient outcomes.
Lijie Zhang, Jiaqi Yao, Yiming Qi, Yongheng Luo, Jun Liu   +4 more
wiley   +1 more source

Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy [PDF]

, 2015
The CXC chemokine receptor (CXCR) 3 and its chemokines (CXCL9, CXCL10, CXCL11) are involved in the pathogenesis of autoimmune disesases. Under the influence of interferon (IFN) γ, the IFNγ-inducible chemokines are secreted by lymphocytes, and by ...
Antonelli, Alessandro, Fallahi, Poupak, FERRARI, Silvia Martina, FERRI, Clodoveo, GIUGGIOLI, DILIA   +4 more
core   +1 more source

Corneal Confocal Microscopy to Diagnose Peripheral Neuropathy: A Systematic Review and Meta‐Analysis

European Journal of Neurology, Volume 32, Issue 11, November 2025.
ABSTRACT Background and Objectives Peripheral neuropathy (PN) may be diagnosed late or may remain undiagnosed. Studies have shown that measurement of corneal nerve fiber length (CNFL) using corneal confocal microscopy (CCM) may have diagnostic utility in diabetic and other peripheral neuropathies. Methods The main databases [CENTRAL, Embase (Ovid), and
Ioannis N. Petropoulos, Omar A. Madani, Hoda Y. Gad, Ziyad R. Mahfoud, Georgios Ponirakis, Ross MacDonald, Rayaz A. Malik   +6 more
wiley   +1 more source

Building the case for insulin-like growth factor receptor-I involvement in thyroid-associated ophthalmopathy [PDF]

, 2017
The pathogenesis of orbital Graves' disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the ...
Janssen, J.A.M.J.L. (Joop), Smith, T.J. (Terry)   +1 more
core   +4 more sources

Double Filtration Plasmapheresis for Thyroid Storm With Encephalopathy: A Case Report

Journal of Clinical Apheresis, Volume 40, Issue 5, October 2025.
ABSTRACT Thyroid storm is a life‐threatening endocrine emergency with a mortality rate of up to 17%. Standard treatment includes antithyroid drugs (ATD), β‐blockers, and glucocorticoids. However, some patients may require blood purification therapies, such as plasmapheresis, due to the ineffectiveness of standard treatments or contraindications like ...
Qisheng Lin, Haijiao Jin, Yao Xu, Yuanyuan Xie, Yijun Zhou, Renhua Lu   +5 more
wiley   +1 more source

Graves’ ophthalmopathy: the clinical and psychosocial outcomes of different medical interventions – a systematic review

BMJ Open Ophthalmology
Background Graves’ ophthalmopathy is a complex autoimmune disorder that can significantly affect quality of life (QoL), vision and physical appearance.
Maralyn Druce, Ejaz Ansari, Oyinlola Maria Bello   +2 more
doaj   +1 more source