Results 21 to 30 of about 268,622 (261)

The Role of Adipsin, Complement Factor D, in the Pathogenesis of Graves' Orbitopathy. [PDF]

Invest Ophthalmol Vis Sci, 2023
Purpose Graves’ orbitopathy (GO) is an orbital manifestation of autoimmune Graves’ disease, and orbital fibroblast is considered a target cell, producing pro-inflammatory cytokines and/or differentiating into adipocytes.
Byeon HJ, Chae MK, Ko J, Lee EJ, Kikkawa DO, Jang SY, Yoon JS.   +6 more
europepmc   +2 more sources

Influence of biological sex, age and smoking on Graves’ orbitopathy – a ten-year tertiary referral center analysis

Frontiers in Endocrinology, 2023
Purpose Severity of Graves’ orbitopathy (GO) shows wide individual differences. For optimal treatment, it is important to be able to predict the natural course of the disease as accurate as possible to counteract with anti-inflammatory and surgical ...
Michael Oeverhaus, Luisa Winkler, K. Stähr, A. Daser, Nikolaos Bechrakis, Mareile Stöhr, Ying Chen, A. Eckstein   +7 more
semanticscholar   +1 more source

Deep learning-based diagnosis of disease activity in patients with Graves’ orbitopathy using orbital SPECT/CT

European Journal of Nuclear Medicine and Molecular Imaging, 2023
Orbital [99mTc]TcDTPA orbital single-photon emission computed tomography (SPECT)/CT is an important method for assessing inflammatory activity in patients with Graves’ orbitopathy (GO).
Ni Yao, Longxi Li, Zhengyuan Gao, Chen Zhao, Yanting Li, Chuang Han, Jiaofen Nan, Zelin Zhu, Yi Xiao, Fubao Zhu, Min Zhao, Weihua Zhou   +11 more
semanticscholar   +1 more source

Tocilizumab improves clinical outcome in patients with active corticosteroid-resistant moderate-to-severe Graves’ orbitopathy: an observational study

Frontiers in Endocrinology, 2023
Background Graves’ orbitopathy (GO) is an autoimmune disorder affecting the orbital fat and muscles. A significant role of IL-6 in the pathogenesis of GO has been described and tocilizumab (TCZ), an IL-6 inhibitor targeting IL-6R has been given in some ...
G. Boutzios, S. Chatzi, A. Goules, Areti Mina, G. Charonis, P. Vlachoyiannopoulos, A. Tzioufas   +6 more
semanticscholar   +1 more source

Sex-specific risk factors associated with graves’ orbitopathy in Korean patients with newly diagnosed graves’ disease

Eye, 2023
To assess sex-specific risk factors for Graves’ orbitopathy (GO) in newly diagnosed Graves’ disease (GD) patients. A retrospective cohort study was conducted using the National Health Insurance Service’s sample database, which consisted of 1,137,861 ...
Jooyoung Lee, Jinmo Kang, H. Y. Ahn, Jeong Kyu Lee   +3 more
semanticscholar   +1 more source

Nonsurgical treatment for upper eyelid retraction in patients with inactive Graves’ orbitopathy

International ophtalmology, 2023
Purpose To evaluate the effectiveness of incobotulinumtoxinA (Xeomin^®) in treating upper eyelid retraction in patients with Graves orbitopathy (GO) initially scheduled for surgery via two different application sites.
Sandra Vokurka Topljak, Martina Galiot Delić, K. Mandic, S. Perić, M. Baretić, J. Juri Mandic   +5 more
semanticscholar   +1 more source

Prognostic significance of thyroid-stimulating hormone receptor antibodies in moderate-to-severe graves’ orbitopathy

Frontiers in Endocrinology, 2023
Design Retrospective study Purpose The purpose of this retrospective study was to assess the changes in thyroid-stimulating hormone receptor (TSH-R) antibody levels following treatment in patients with moderate-to-severe and active Graves’ orbitopathy ...
Jungyul Park, Jae Hyun Kim, Sang Soo Kim, H. Choi   +3 more
semanticscholar   +1 more source

The role of hormonal imbalance in the development of autoimmune dacryoadenitis in endocrine orbitopathy

Oftalʹmologiâ, 2014
The authors analyzed the hormonal profile of patients with Graves’ disease and endocrine orbitopathy with or without autoimmune dacryoadenitis.
V. G. Likhvantseva, T. N. Safonova, O. A. Gontyurova, E. A. Rudenko, V. A. Vygodin   +4 more
doaj   +3 more sources

Asymmetric Graves’ Orbitopathy

Frontiers in Endocrinology, 2020
Graves’ Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. The presence of GO is associated with increased psychological burden and, in severe cases may cause blindness.
Grigorios Panagiotou, Petros Perros
doaj   +1 more source

Factors Predicting Long-term Outcome and the Need for Surgery in Graves Orbitopathy: Extended Follow-up From the CIRTED Trial

Journal of Clinical Endocrinology and Metabolism, 2023
Graves orbitopathy is both disabling and disfiguring. Medical therapies to reduce inflammation are widely used, but there is limited trial data beyond 18 months of follow-up.
Peter Taylor, R. Rajendram, S. Hanna, Victoria Wilson, J. Pell, Chunhei Li, A. Cook, R. Gattamaneni, N. Plowman, S. Jackson, R. Hills, R. French, J. Uddin, Richard Lee, C. Dayan   +14 more
semanticscholar   +1 more source