Results 11 to 20 of about 280,326 (218)

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition. [PDF]

Adv Sci (Weinh)
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Zhang Y, Wu E, Liu W, Zeng L, Ling N, Wang H, Li Z, Yao S, Pan T, Li X, Huang Y, Li X, Tu Y, Yan W, Wu J, Ye M, Wu W.   +16 more
europepmc   +2 more sources

A Case of Thyrotoxic Periodic Paralysis and Graves’ Ophthalmopathy Patient in Coincidence with Chronic Hepatitis B Infection

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2022
Graves' disease is an autoimmune thyroid disease with several characteristic symptoms and signs. Graves' ophthalmopathy, an inflammatory disease in the orbital area, is the main extrathyroid manifestation of Graves' disease.
Herry Krisnata Ginting, Soebagijo Adi
doaj   +1 more source

Application of Multiparameter Quantitative Magnetic Resonance Imaging in the Evaluation of Graves' Ophthalmopathy

Journal of Magnetic Resonance Imaging, 2023
Assessment of the activity of Graves' ophthalmopathy (GO) is difficult. Existing methods need improvement.
Zhangfang Li, Yaosheng Luo, Xiaoting Feng, Qing Zhang, Qiang Zhong, Chanyan Weng, Zhi Chen, Jie Shen   +7 more
semanticscholar   +1 more source

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis

Journal of Clinical Endocrinology and Metabolism, 2016
Christine C Krieger, Robert F Place, Brent S Abel   +2 more
exaly   +2 more sources

Current insights of applying MRI in Graves’ ophthalmopathy

Frontiers in Endocrinology, 2022
Graves’ ophthalmopathy (GO) is an autoimmune disease related to Grave’s disease (GD). The therapeutic strategies for GO patients are based on precise assessment of the activity and severity of the disease.
C. Song, Yaosheng Luo, Gaofeng Yu, Haixiong Chen, Jie Shen   +4 more
semanticscholar   +1 more source

Emerging Insights Into the Role of Epigenetics and Gut Microbiome in the Pathogenesis of Graves’ Ophthalmopathy

Frontiers in Endocrinology, 2022
Graves’ Ophthalmopathy (GO) is an organ-specific autoimmune disease that is often characterized by infiltration of orbital tissues and is considered as the most common extra-thyroid manifestation of Graves’ disease (GD).
Yan Wang, Xiao-Min Ma, Xin Wang, Xin Sun, Ling Wang, Xin-Qi Li, Xiaoyang Liu, Hongyang Yu   +7 more
semanticscholar   +1 more source

Tear-derived exosomal biomarkers of Graves’ ophthalmopathy

Frontiers in Immunology, 2022
Graves’ ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves’ disease (GD), can lead to a significant decline in the quality of life in patients.
Tingting Shi, Ruxuan Zhao, Z. Xin, Z. Hou, Hua Wang, Rongrong Xie, Dong-mei Li, Jin-Kui Yang   +7 more
semanticscholar   +1 more source

The Role of Oxidative Stress and Therapeutic Potential of Antioxidants in Graves’ Ophthalmopathy

Biomedicines, 2021
Graves’ ophthalmopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease. It is characterized initially by an inflammatory process, followed by tissue remodeling and fibrosis, leading to proptosis, exposure keratopathy, ocular ...
Tzu-Yu Hou, Shi-Bei Wu, H. Kau, Chieh-Chih Tsai   +3 more
semanticscholar   +1 more source

Cytokines as Targets of Novel Therapies for Graves’ Ophthalmopathy

Frontiers in Endocrinology, 2021
Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid, which is characterized by circulating TSH-receptor (TSH-R) stimulating antibodies (TSAb), leading to hyperthyroidism.
P. Fallahi, S. Ferrari, G. Elia, F. Ragusa, S. Paparo, A. Patrizio, S. Camastra, M. Miccoli, G. Cavallini, S. Benvenga, A. Antonelli   +10 more
semanticscholar   +1 more source

Ocular surface changes in Graves' ophthalmopathy.

International Journal of Ophthalmology, 2021
Many patients with Graves' ophthalmopathy (GO) suffer from dry eye syndrome (DES), and this is one of the most common reasons of eye discomfort in patients with GO.
Rou Sun, Huifang Zhou, Xian-qun Fan
semanticscholar   +1 more source