Results 11 to 20 of about 9,066 (175)

Teprotumumab for Thyroid-Associated Ophthalmopathy [PDF]

New England Journal of Medicine, 2017
BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves’ disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns ...
Antonelli, A, Couch, SM, Dailey, RA, Douglas, RS, Ezra, DG, Fleming, JC, Gabriel, K, Gigantelli, JW, Goldberg, RA, Harris, GJ, Hayek, BR, Hink, EM, Kahaly, GJ, Magni, G, Salvi, M, Shriver, EM, Smith, TJ, Tang, RA, Woodward, RM   +18 more
core   +3 more sources

TSHR-Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition. [PDF]

Adv Sci (Weinh)
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Zhang Y, Wu E, Liu W, Zeng L, Ling N, Wang H, Li Z, Yao S, Pan T, Li X, Huang Y, Li X, Tu Y, Yan W, Wu J, Ye M, Wu W.   +16 more
europepmc   +2 more sources

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source

Graves' ophthalmopathy [PDF]

, 2009
A 40-year-old woman who recently received a diagnosis of Graves' disease comes for a follow-up visit. She has been taking methimazole, at a dose of 10 mg daily, and is now euthyroid, but for the past 3 months, she has had bothersome eye symptoms ...
Bartalena, Luigi, Tanda, Maria Laura Piera   +1 more
core   +1 more source

Prognostic indicators for the development of strabismus among patients with graves’ ophthalmopathy

Journal of Clinical & Translational Endocrinology, 2017
Objective: Thyroid eye disease (TED), an autoimmune inflammatory process involving the orbital tissues around the eye, is the most common extra-thyroidal manifestation of Graves’ disease (GD). Due to changes in the patient’s appearance, TED is a socially
Tiffany Y. Lin, Ning Li, Michael W. Yeh, Angela M. Leung, Daniel B. Rootman   +4 more
doaj   +1 more source

HUBUNGAN FAKTOR RISIKO TERHADAP KEJADIAN OPHTHALMOPATHY GRAVES

Jurnal Kedokteran Diponegoro, 2019
Latar Belakang: Opthalmopathy Graves merupakan salah satu tanda adanya penyakit Graves; penyakit autoimun dengan inflamasi sistemik. OG bisa terjadi pada penyakit Graves yang fungsi tiroidnya hipertiroidisme, eutiroidisme dan hipotiroidisme.
Y. Andressa Nugroho W., Charles Limantoro, A. Kentar Arimadyo   +2 more
doaj   +1 more source

Inactive Graves' ophthalmopathy and self-esteem [PDF]

, 2008
PURPOSE: To assess the self-esteem of Graves' ophthalmopathy patients in the inactive phase. METHODS: Thirty euthyroid patients were evaluated in the inactive phase of disease with age ranging from 26 to 65 years, average of 43 ± 11,0 years, called study
Ferreira, Lydia Masako, Magalhães, Carlos Henrique de Toledo, Manso, Paulo Góis, Novo, Neil Ferreira, Pereira, Max Domingues, Veiga, Daniela Francescato   +5 more
core   +2 more sources

The Efficiacy of High Dose Pulse Steroid (Methylprednisolone) Therapy in Graves Ophthalmopathy

Endocrinology Research and Practice, 2022
Thyroid ophthalmopathy is the most common cause of bilateral or unilateral proptosis in adults. Since the recognition of autoimmune mechanisms in the pathogenesis of Graves' ophthalmopathy, a number of investigators have reported on the use of various ...
Bilgin Özmen, Esin Erkin, Murat Saruç
doaj   +2 more sources

The thickness of the retrobulbar portion of the optic nerve in Graves ophthalmopathy measured by ultrasound [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction. The clinical diagnostic of Graves ophthalmopathy is based on the association of ocular signs and the disease of the thyroid gland. The evolution of the disease involves the development of eye globe protrusion, extraocular muscle thickening ...
Stefanović Ivan, Paović Jelena, Kovačević Igor, Paović Predrag   +3 more
doaj   +1 more source

Management of patients with Graves' disease and orbital involvement: role of spectral domain optical coherence tomography [PDF]

, 2018
PURPOSE: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO).
Bruscolini, A, Gharbiya, M, La Cava, M, Lambiase, A, Marenco, M, Nardella, C, Restivo, L, Sacchetti, M   +7 more
core   +1 more source