Results 31 to 40 of about 301,894 (280)
Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega +10 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
What has changed in thyroid eye disease in the last five years (2020–2025)
European Thyroid JournalBackground: Significant progress has been made in the management of thyroid eye disease (TED), based on the elucidation of important pathogenic mechanisms. This has led to novel therapeutics validated in randomized clinical trials.
Mario Salvi
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Vinča Burials in the Research of Miloje M. Vasić
Etnoantropološki Problemi, 2020 Miloje M. Vasić (1869–1956) is considered to be the founding father of Serbian archaeology. This paper directly challenges, as based on detailed archival research, the prevailing view that his excavation of the Vinča archaeological site is a model ...
Aleksandar Palavestra +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Notes on the origin and dating of the bone pyxides from the Sarmatian environment between the Don and the Prut [PDF]
Plural: History, Culture, Society, 2019 The object of this article is to discuss the bone pyxides discovered in the Sar¬matian graves from the north and north-west of the Black Sea. The study, with¬out being exhaustive, attempts a presentation of the graves where bone pyxides were identified ...
Vitalie Bârcă
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Diagnostic and Follow-up Characteristics of Cases Presenting with Hyperthyroidism in Childhood
Güncel PediatriIntroduction: Hyperthyroidism is a disease characterized by high total T4, T3, free T4, T3, and suppressed thyroid stimulating hormone (TSH), most seen in childhood due to Graves’ disease. This study aimed to examine the diagnostic features and treatment
Yasemin Denkboy Öngen, Özlem Kara
doaj +1 more source