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Treatment of Graves’ ophthalmopathy
Medicina Clínica (English Edition), 2021Graves' ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and the orbit. It encompasses the most common extra-thyroid manifestation in patients with Graves-Basedow disease. The underlying cause is molecular mimicry with the TSH receptor in ocular fibroblasts, leading to an immuno-mediated pathogenesis ...
Andrés, González-García +1 more
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IMMUNOGENETICS OF GRAVES' OPHTHALMOPATHY
Clinical Endocrinology, 1988SUMMARYWe have performed an immunogenetic analysis of 53 patients with severe Graves' ophthalmopathy, 51 patients with Graves' disease but little or no clinically apparent eye disease, and 90 controls. The distribution of restriction fragment length polymorphisms was analysed in the three groups, using probes for the HLA‐DQα and DRβ regions, the T‐cell
A P, Weetman +5 more
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Inducing Graves’ ophthalmopathy
Journal of Endocrinological Investigation, 2004The majority of patients with Graves' disease (GD) have some degree of ocular involvement and this requires surgical or medical intervention in about 5% of cases. There are autoimmune and inflammatory processes operating in Graves' ophthalmopathy (GO), which together induce glycosaminoglycan production, edema and adipogenesis resulting in an increase ...
M, Ludgate, G, Baker
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Current Opinion in Ophthalmology, 2001
Graves ophthalmopathy (GO) is an autoimmune disease that typically affects the thyroid gland and the orbit. The roles of the thyroid stimulating hormone receptor and cellular and humoral immunity in the pathogenesis of GO are being investigated. Investigators are gaining insights into the epidemiology of GO as it relates to other ocular and autoimmune ...
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Graves ophthalmopathy (GO) is an autoimmune disease that typically affects the thyroid gland and the orbit. The roles of the thyroid stimulating hormone receptor and cellular and humoral immunity in the pathogenesis of GO are being investigated. Investigators are gaining insights into the epidemiology of GO as it relates to other ocular and autoimmune ...
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Medical Clinics of North America, 1995
Graves' ophthalmopathy is an organ-specific autoimmune process strongly linked to Graves' hyperthyroidism. Although the hyperthyroidism can be successfully treated, it is often the ophthalmopathy that produces the greatest long-term disability for patients suffering from this disease.
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Graves' ophthalmopathy is an organ-specific autoimmune process strongly linked to Graves' hyperthyroidism. Although the hyperthyroidism can be successfully treated, it is often the ophthalmopathy that produces the greatest long-term disability for patients suffering from this disease.
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Prevention of Graves’ ophthalmopathy
Best Practice & Research Clinical Endocrinology & Metabolism, 2012Smoking is the most important risk factor for the occurrence/progression of Graves' ophthalmopathy (GO), as well as for its lower/slower response to immunosuppression. Accordingly, refrain from smoking should be urged, both as primary prevention (removal of risk factors in Graves' patients without GO), secondary prevention (early detection and ...
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Ciclosporine and Graves’ Ophthalmopathy
Hormone Research, 2008The pharmacological treatment of Graves’ ophthalmopathy remains unsatisfactory due to the limited efficacy and severe side effects of the available drugs. Ciclosporine, an immunosuppressive drug has recently been used with the aim of controlling the autoimmune process considered to be responsible for the disease.
J P, Gayno, G, Strauch
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Canadian Medical Association journal, 1981
Graves' ophthalmopathy usually occurs in association with hyperthyroidism. Its occasional occurrence in the absence of thyroid disease suggests, however, that it may be a separate autoimmune disorder. While the evidence supporting an autoimmune pathogenesis is considerable for the ophthalmopathy, it is not so impressive as that for Graves ...
Wall, JR +3 more
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Graves' ophthalmopathy usually occurs in association with hyperthyroidism. Its occasional occurrence in the absence of thyroid disease suggests, however, that it may be a separate autoimmune disorder. While the evidence supporting an autoimmune pathogenesis is considerable for the ophthalmopathy, it is not so impressive as that for Graves ...
Wall, JR +3 more
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THE MANAGEMENT OF Graves' OPHTHALMOPATHY
Clinical Endocrinology, 1989L'auteur decrit les differentes lesions de l'ophtalmopathie basedowienne et passe en revue les moyens therapeutiques disponibles: traitement chimique et chirurgical de l'affection thyroidienne, traitement immunosuppresseur, traitements antiinflammatoires locaux et correction chirurgicale.
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Ophthalmopathy of Graves' Disease
New England Journal of Medicine, 1983Soft-tissue swelling that would be innocuous in many locations has serious effects where local anatomy confines the swelling tissues within an inexpansible space. The anterior-tibial-compartment and carpal-tunnel syndromes are good examples of such conditions. The severe ophthalmopathy of Graves' disease is another.
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