Results 71 to 80 of about 9,117 (217)
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng +14 more
wiley +1 more source
Blepharoplasty in Graves’ Ophthalmopathy
Craniomaxillofacial Trauma & Reconstruction Open, 2017 Graves’ ophthalmopathy (GO) is the main extrathyroidal manifestation of Graves’ disease. Many patients require rehabilitative surgery, such as orbital decompression and lipectomy, to restore function and appearance. Graves’ lower eyelid retraction is a common, controversial sign and is resolved in most cases by eyelid surgery, which is very effective ...
Bocchialini, Gabriele +2 more
openaire +2 more sources
Glymphatic System Dysfunction in Thyroid‐Associated Ophthalmopathy: A Multimodal MRI Study
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.TAO patients exhibit impaired glymphatic function, with reduced DTI‐ALPS indices and gBOLD‐CSF coupling, but unchanged choroid plexus volume. These alterations correlate with neuropsychological symptoms and sleep disturbances. Restoring glymphatic activity may offer a therapeutic approach to enhance patient outcomes.
Lijie Zhang +4 more
wiley +1 more source
Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy [PDF]
, 2015 The CXC chemokine receptor (CXCR) 3 and its chemokines (CXCL9, CXCL10, CXCL11) are involved in the pathogenesis of autoimmune disesases. Under the influence of interferon (IFN) γ, the IFNγ-inducible chemokines are secreted by lymphocytes, and by ...
Antonelli, Alessandro +4 more
core +1 more source
Corneal Confocal Microscopy to Diagnose Peripheral Neuropathy: A Systematic Review and Meta‐Analysis
European Journal of Neurology, Volume 32, Issue 11, November 2025.ABSTRACT Background and Objectives Peripheral neuropathy (PN) may be diagnosed late or may remain undiagnosed. Studies have shown that measurement of corneal nerve fiber length (CNFL) using corneal confocal microscopy (CCM) may have diagnostic utility in diabetic and other peripheral neuropathies. Methods The main databases [CENTRAL, Embase (Ovid), and
Ioannis N. Petropoulos +6 more
wiley +1 more source
Building the case for insulin-like growth factor receptor-I involvement in thyroid-associated ophthalmopathy [PDF]
, 2017 The pathogenesis of orbital Graves' disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the ...
Janssen, J.A.M.J.L. (Joop) +1 more
core +4 more sources
Treatment of Graves' ophthalmopathy with Cyclosporin A [PDF]
Acta Endocrinologica, 1984 To evaluate the effect of Cyclosporin A in the management of Graves' ophthalmopathy, we treated 13 patients with severe euthyroid endocrine eye disease with the immunosuppressive drug. Follow up consisted of clinical investigation, laboratory evaluation with detailed thyroid function tests and complete ophthalmological assessments including A and B ...
A, Witte +5 more
openaire +2 more sources
Double Filtration Plasmapheresis for Thyroid Storm With Encephalopathy: A Case Report
Journal of Clinical Apheresis, Volume 40, Issue 5, October 2025.ABSTRACT Thyroid storm is a life‐threatening endocrine emergency with a mortality rate of up to 17%. Standard treatment includes antithyroid drugs (ATD), β‐blockers, and glucocorticoids. However, some patients may require blood purification therapies, such as plasmapheresis, due to the ineffectiveness of standard treatments or contraindications like ...
Qisheng Lin +5 more
wiley +1 more source
Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation [PDF]
, 2012 published_or_final_versio
Au, GKH +6 more
core +1 more source
Treatment of ophthalmopathy in the course of Graves’ disease
Journal of Education, Health and Sport, 2019 : Introduction: Graves’ disease is an autoimmune disease in which the TSH receptor (TSHR) is an autoantigen. Its stimulation by antibodies inhibiting thyrotropin binding causes increased secretion of free thyroid hormones and consequently symptoms of ...
Magdalena Woźniak +5 more
doaj +3 more sources