Results 201 to 210 of about 297,779 (263)

M1-Like Macrophages Modulate Fibrosis and Inflammation of Orbital Fibroblasts in Graves' Orbitopathy: Potential Relevance to Soluble Interleukin-6 Receptor

Thyroid, 2023
Background: Graves' orbitopathy (GO) is a disfiguring and sight-threatening autoimmune disease. Previous studies have shown the infiltration of macrophages in GO orbital connective tissues.
Yi Lu   +12 more
semanticscholar   +1 more source

Yes-Associated Protein Mediates the Transition from Inflammation to Fibrosis in Graves' Orbitopathy

Thyroid, 2023
Background: In Graves' orbitopathy (GO), localized orbital inflammation within the fixed orbit often leads to a fibrotic phenotype resulting in restrictive myopathy or refractory proptosis.
JaeSang Ko   +4 more
semanticscholar   +1 more source

[Graves' orbitopathy].

Deutsche medizinische Wochenschrift (1946), 2021
Graves' orbitopathy (GO) is an autoimmune orbital disease which is mostly associated with Graves' disease and requires good interdisciplinary cooperation. To minimize irreversible damages a stage-adapted anti-inflammatory therapy is of great importance.Discussion of the latest results of new findings of the pathogenesis, randomized controlled trials on
Eckstein, Anja   +3 more
openaire   +2 more sources

Imaging in Graves' Orbitopathy

Orbit, 2009
In patients with Graves' orbitopathy, magnetic resonance imaging (MRI) is a useful tool to distinguish the acute inflammatory active disease in demonstrating interstitial edema within the extraocular muscles on coronal TIRM-sequences from fibrotic, inactive endstage disease. MRI is the modality of choice to identify active inflammatory changes in order
Kirsch, Eberhard   +2 more
openaire   +2 more sources

[Graves' orbitopathy].

Klinische Monatsblatter fur Augenheilkunde, 2011
Graves' orbitopathy (GO) is part of an autoimmune systemic disease (prevalence of 0.5 - 2%) which is composed of hyperthyroidism, orbitopathy, dermopathy and acropachy. Stimulating antibodies against the TSH receptor plays the central pathogenetic role and high levels indicate the risk of a severe course of the disease. The main symproms of GO comprise
A, Eckstein, J, Esser
openaire   +3 more sources

Statins for Graves' orbitopathy (STAGO): a phase 2, open-label, adaptive, single centre, randomised clinical trial.

The Lancet Diabetes and Endocrinology, 2021
BACKGROUND A protective action of statins on development of Graves' orbitopathy suggests that statins might be used for treatment of the disease. We aimed to assess the efficacy of the addition of a statin, atorvastatin, to intravenous glucocorticoids ...
G. Lanzolla   +9 more
semanticscholar   +1 more source

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