Results 71 to 80 of about 747,971 (341)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.

PLoS ONE, 2018
BackgroundBrain volume loss is an important surrogate marker for assessing disability in MS; however, contribution of gray and white matter to the whole brain volume loss needs further examination in the context of specific MS treatment.ObjectivesTo ...
Fredrika Koskimäki, Jacqueline Bernard, Jeong Yong, Nancy Arndt, Timothy Carroll, Seon-Kyu Lee, Anthony T Reder, Adil Javed   +7 more
doaj   +1 more source

Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients

Frontiers in Neurology, 2020
Ankylosing spondylitis (AS) mainly affects the axial skeleton and is an important factor leading to chronic lower back pain in young individuals. However, few studies have explored alterations of brain gray matter volume in AS patients.
Kelei Hua, Kelei Hua, Peijun Wang, Zhihong Lan, Meng Li, Wenkai Zhao, Tianyue Wang, Shumei Li, Xiaofen Ma, Chao Li, Shishun Fu, Yi Yin, Ping Liu, Jin Fang, Jin Fang, Tianwang Li, Guihua Jiang, Guihua Jiang   +17 more
doaj   +1 more source

Association of Fatigue and Stress With Gray Matter Volume [PDF]

Frontiers in Behavioral Neuroscience, 2018
Stress is associated with a greater risk for various health problems including reduced gray matter volume (GMV) and density in a number of brain regions. Previous studies show that neuroimaging could be a means to objectively evaluate stress. However, to date, no definite neuroimaging-derived measures are available to detect stress. In this research we
Keisuke Kokubun, Kiyotaka Nemoto, Hiroki Oka, Hiroki Fukuda, Yoshinori Yamakawa, Yoshinori Yamakawa, Yoshinori Yamakawa, Yasuyoshi Watanabe   +7 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Moderating effect of cognitive reserve on brain integrity and cognitive performance

Frontiers in Aging Neuroscience, 2022
BackgroundDementia syndrome is one of the most devastating conditions in older adults. As treatments to stop neurodegeneration become available, accurate and timely diagnosis will increase in importance.
Monica E. Nelson, Britney M. Veal, Ross Andel, Ross Andel, Julie Martinkova, Katerina Veverova, Hana Horakova, Zuzana Nedelska, Jan Laczó, Martin Vyhnalek, Jakub Hort   +10 more
doaj   +1 more source

Regional reductions of gray matter volume in familial dyslexia [PDF]

Neurology, 2004
An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, inferior temporal cortex, and cerebellar nuclei, suggesting that the underlying anatomic ...
Brambati, S. M., Termine, C., Ruffino, M., STELLA, GIACOMO, Fazio, F., Cappa, S. F, Perani, D.   +6 more
openaire   +5 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Depressive symptoms and neuroanatomical structures in community-dwelling women: A combined voxel-based morphometry and diffusion tensor imaging study with tract-based spatial statistics

NeuroImage: Clinical, 2014
Depressive symptoms, even at a subclinical level, have been associated with structural brain abnormalities. However, previous studies have used regions of interest or small sample sizes, limiting the ability to generalize the results.
Yayoi K. Hayakawa, Hiroki Sasaki, Hidemasa Takao, Naoto Hayashi, Akira Kunimatsu, Kuni Ohtomo, Shigeki Aoki   +6 more
doaj   +1 more source

Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study [PDF]

, 2010
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: To examine the association of glycemic status to magnetic resonance imaging indicators of brain pathological changes. RESEARCH DESIGN
Saczynski, Jane S, Siggurdsson, Sigurdur, Jonsson, Palmi V, Eiriksdottir, Gudny, Olafsdottir, Elin, Kjartansson, Olafur, Harris, Tamara B, van Buchem, Mark A, Gudnason, Vilmundur, Launer, Lenore J   +9 more
core   +1 more source