Results 81 to 90 of about 747,971 (341)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults [PDF]

, 2017
Rationale: Obstructive sleep apnea causes intermittent hypoxemia, hemodynamic fluctuations, and sleep fragmentation, all of which could damage cerebral gray matter that can be indirectly assessed with neuroimaging.
Baril, Andrée-Ann, Brayet, Pauline, Carrier, Julie, De Beaumont, Louis, Gagnon, Jean-François, Gagnon, Katia, Gosselin, Nadia, Lafond, Chantal, L’Heureux, Francis, Montplaisir, Jacques-Yves   +9 more
core   +1 more source

Reduced gray matter volume in male adolescent violent offenders

PeerJ, 2019
Background Previous studies reported that reduced gray matter volume (GMV) was associated with violent-related behaviors. However, the previous studies were conducted on adults and no study has studied the association between GMV and violent behaviors on adolescents.
Ying-Dong Zhang, Jian-Song Zhou, Feng-Mei Lu, Xiao-Ping Wang   +3 more
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Comparison between Schizophrenia and Autism [PDF]

, 2014
Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in brain structure.
Bölte, Sven, Ciaramidaro, Angela, Freitag, Christine Margarete, Hainz, Daniela, Poustka, Fritz, Radeloff, Daniel, Schlitt, Sabine, Siniatchkin, Michael, Walter, Henrik, Weber, Bernhard   +9 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation

Frontiers in Neurology, 2020
To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic ...
Jian-zhong Lin, Hong-hua Zheng, Qi-lin Ma, Chen Wang, Li-ping Fan, Han-ming Wu, Dan-ni Wang, Jia-xing Zhang, Yi-hong Zhan   +8 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Alterations of brain gray matter volume in children with obstructive sleep apnea

Frontiers in Neurology, 2023
ObjectiveObstructive sleep apnea (OSA) seriously affects the children's cognitive functions, but the neuroimaging mechanism of cognitive impairment is still unclear. The purpose of our study was to explore the difference in brain local gray matter volume
Chenyi Yu, Yuchuan Fu, Yi Lu, Yinyin Huang, Fangfang Chen, Jiayun Wei, Lingling Li, Janet Akoto Ampadu, Yu Wang, Weikun Zheng, Changcan Jiang, Weiyuan Li, Su Lui, Su Lui, Xiaohong Cai   +14 more
doaj   +1 more source

Effects of current smoking severity on brain gray matter volume in opioid use disorder – a voxel-based morphometry study [PDF]

, 2023
Zhenhao Shi, Xinyi Li, Juliana I. Byanyima, Charles P. O’Brien, Anna Rose Childress, Kevin G. Lynch, James Loughead, Corinde E. Wiers, Daniel D. Langleben   +8 more
openalex   +1 more source