Results 111 to 120 of about 138,138 (280)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

THE ALL-SOURCE GREEN’S FUNCTION AND ITS APPLICATIONS TO TSUNAMI PROBLEMS [PDF]

open access: yesScience of Tsunami Hazards, 2007
The classical Green’s function provides the global linear response to impulse forcing at a particular source location. It is a type of one-source-all-receiver Green’s function.
ZHIGANG XU
doaj  

REDUCED p-MODULUS, p-HARMONIC RADIUS AND p-HARMONIC GREEN’S MAPPINGS

open access: yesПроблемы анализа, 2018
We consider the definitions and properties of the metric characteristics of the spatial domains previously introduced by the author, and their connection with the class of mappings, the particular case of which are the harmonic Green’s mappings ...
B. E. Levitskii
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

STRONG SHORT-RANGE INTERACTIONS IN ONE-DIMENSIONAL PROTON CONDUCTOR

open access: yesCondensed Matter Physics, 2003
The behaviour of one-dimensional proton conductor is investigated on the basis of orientational-tunnelling model. The previously proposed technique which permits the proton interactions to be taken into account in the zero-order Hamiltonian, and is based
I.V.Stasyuk, O.Vorobyov
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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