Results 81 to 90 of about 8,592,856 (257)

Modified GAPI (MoGAPI) Tool and Software for the Assessment of Method Greenness: Case Studies and Applications

Analytica
: The green analytical procedure index (GAPI) has been widely used to assess the greenness of different steps in analytical methodology. In the GAPI index, the different stages of the chemical analysis process are depicted using five pentagrams divided ...
Fotouh R. Mansour, Justyna Płotka-Wasylka, Marcello Locatelli   +2 more
doaj   +1 more source

DEVELOPMENT AND VALIDATION OF GREEN HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF DAPAGLIFLOZIN AND LINAGLIPTIN IN COMBINED DOSAGE FORM [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
A simple, accurate, rapid, sensitive and green high performance thin layer chromatography (HPTLC) technique was developed for the simultaneous determination of Dapagliflozin (DAPA) and Linagliptin (LINA) in pure and pharmaceutical dosage form ...
Dhyey Shah, Dhananjay Meshram, Dhara Patel, Prasanna Pradhan, Grishma Patel   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Green analytical methods and principles of green analytical chemistry

The chemical field, in previous years, has worked through a linear process, and this type of trend caused large waste volume and accumulation, leading to the current crisis of pollution and the environment.
Samanidou, Victoria F., Perrucci, Miryam, Locatelli, Marcello, Ulusoy, Halil Ibrahim, Mansour, Fotouh R., Kabir, Abuzar, Ali, Imran   +6 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Lemon zest-derived N,S-doped carbon quantum dots as a highly sensitive and sustainable fluorescent probe for cefoxitin sodium determination

Talanta Open
Cefoxitin (CEF), classified as a semisynthetic beta-lactam second-generation cephalosporin antibiotic, can be used against many aerobic and anaerobic bacterial infections. Elevated aspartate aminotransferase levels and a higher prevalence of eosinophilia
Ahmed M. Abdel-Raoof, Ebrahim A. El-Desouky, Ahmed M. Abdelzaher, Reem H. Obaydo   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Introduction and overview of applications related to green solvents used in sample preparation

Sample preparation is critical to the entire analytical procedure because it enables precise and accurate analyte evaluation by removing matrix challenges.
Fesliyan, Seçkin, Altunay, Nail, Muhamad, Zainab Hassan, Haq, Hameed Ul, Azooz, Ebaa Adnan, Tuzen, Mustafa   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integration of sustainable spectrophotometric methods and AI-driven data analysis for simultaneous determination of carvedilol, hydrochlorothiazide and a toxic impurity

Green Analytical Chemistry
This study explores the innovative spectrophotometric methods enhanced with artificial intelligence (AI) driven techniques for the precise detection of compounds carvedilol (CAR) and hydrochlorothiazide (HCT) in combined medicine which is regarded one of
Mona Nabil, Nancy W. Nashat, Hoda M. Marzouk, Samah S. Abbas, Hayam M. Lotfy   +4 more
doaj   +1 more source