Results 81 to 90 of about 960,262 (264)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analyses elucidate the regulatory role of SlBEL11 in tomato fruit ripening

Frontiers in Plant Science
Transcription factors serve as key regulators in orchestrating fruit ripening, modulating gene expression networks that govern physiological processes such as color change, texture softening, and sugar accumulation in response to hormonal signals like ...
Xiufen Dong, Xiufen Dong, Jie Lu, Jie Lu, Yun Guo, Yun Guo, Qihan Zhang, Qihan Zhang, Qin Yang, Qin Yang, Jingyi Peng, Jingyi Peng, Li Tian, Li Tian   +13 more
doaj   +1 more source

Ectoparasitic flies of bats (Mammalia: Chiroptera) in urban green areas of northeastern Brazil. [PDF]

Parasitol Res, 2023
Bezerra RHS, Bocchiglieri A.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Identification and evolutionary analysis of NAC transcription factors in Eriobotrya japonica: implications for sugar-acid regulatory networks during fruit development

Frontiers in Plant Science
Loquat (Eriobotrya japonica) is an important subtropical evergreen fruit tree of the Rosaceae family that possesses significant edible and economic value. The NAC transcription factor family, as plant-specific regulatory factors, not only participated in
Huiling Zhang, Meng Yang, Chengyang Ye, Minghui Chen, Hailing Gu, Xiurun Fan, Chencong Yang, Junwei Chen, Kai Xu, Boping Wu   +9 more
doaj   +1 more source

Assessing the Role of Urban Green Areas for Students' Quality of Life during the COVID-19 Pandemic. [PDF]

Iran J Public Health, 2022
Choi KA, Rezaei M.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assessing the Correlation between Neighborhood Green Areas and the Perceived Mental Health of Residents in Metropolitan Areas. [PDF]

Iran J Public Health, 2022
Choi KA, Rezaei M.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metagenomics enables the first detection of Trypanosoma sp. in Streblidae (Diptera: Hippoboscoidea) parasitizing bats in São Paulo, Brazil

Frontiers in Systems Biology
IntroductionBats play important ecological roles but can also harbor a wide diversity of pathogens, including trypanosomatids. Knowledge about the circulation of Trypanosoma spp.
Roberta Marcatti, Roberta Marcatti, Lucas Augusto Moysés Franco, Esmenia Coelho Rocha, Marcello Schiavo Nardi, Juliana Laurito Summa, Eric Thal Brambilla Cordeiro da Silva, Adriana Ruckert da Rosa, Débora Cardoso de Oliveira, Gustavo Graciolli, Ester Cerdeira Sabino   +10 more
doaj   +1 more source