Results 101 to 110 of about 827,595 (342)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Multi-Faceted Analysis of Green Building Certification to Expand Green Buildings in South Korea

open access: yesBuildings
Many countries have green building certification systems to rate a green building. They have played a pivotal role in promoting the adoption of green buildings.
Young-Sun Jeong
doaj   +1 more source

Adoption of dynamic simulation for an energy performance rating tool for Korean residential buildings : EDEM-SAMSUNG [PDF]

open access: yes, 2009
Currently, there is a high emphasis on reducing the energy consumption and carbon emissions of buildings worldwide. Korea is facing an emerging issue of energy savings in buildings in perspective of new green economic policy.
Ghauri, Sabeeta   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

A study on factors undermining the incorporation of green principles into the Design Development Stage of building projects in the Gauteng Province of South Africa [PDF]

open access: yes, 2015
A research report submitted to the Faculty of Engineering and the Built Environment, University of the Witwatersrand Johannesburg, in partial fulfilment of the requirements for the degree of Masters of Science in Property Development and ...
Kiggundu, Davis Wasswa
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

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