Results 91 to 100 of about 12,534,618 (262)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The implementation of practical work in chemistry, along with the principles of green chemistry and sustainable chemistry, in Portugal

Chemistry Teacher International
Since the late twentieth century, global sustainability and greener chemistry have become essential human goals. Education is crucial in driving this change by enhancing scientific knowledge and literacy.
Ribau Isabel
doaj   +1 more source

CALB Immobilized onto Magnetic Nanoparticles for Efficient Kinetic Resolution of Racemic Secondary Alcohols: Long-Term Stability and Reusability

Molecules, 2019
In this study, an immobilization strategy for magnetic cross-linking enzyme aggregates of lipase B from Candida antarctica (CALB) was developed and investigated. Magnetic particles were prepared by conventional co-precipitation.
Xiu Xing, Jun-Qi Jia, Jing-Fan Zhang, Zi-Wen Zhou, Jun Li, Na Wang, Xiao-Qi Yu   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Synthesis and redox catalysis of Carbodiphosphorane ligated stannylene

Nature Communications
Heavier group 14 carbene analogues, exhibiting transition-metal-like behavior, display remarkable capability for small molecule activation and coordination chemistry. However, their application in redox catalysis remains elusive. In this paper, we report
Zhuchunguang Liu, Zhijun Wang, Huan Mu, Yihan Zhou, Jiliang Zhou, Zhaowen Dong   +5 more
doaj   +1 more source

Green Chemistry Education: Recent Developments Green chemical processing ;, vol. 4./ Mark Anthony Benvenuto and Larry Kolopajlo.

, 2019
In English.Includes bibliographical references and index.Kolopajlo, Larry / Benvenuto, Mark -- Noce, Anthony M. -- Berger, Michael / Karod, Madeline / Goldfarb, Jillian L. -- Sadraei, S. Iraj / Onge, Brent St / Trant, John F.
Krikke James., Pothoof Justin., Kolopajlo Lawrence H.,, Berger Michael., Kohn Craig., Onge Brent S., Sliwinski Ben D., Ruprecht Michal., Benvenuto (Mark Anthony),, Sosnowski Ben M., Fitzgerald Polly R., Wathen Steven P., Goldfarb Jillian L., Kosmas Steven., Kovacs Dalila., Ause Robert., Mack Kristina., Noce Anthony., Patel Jay M., Sadraei S. Iraj., Trant John F., Karod Madeline., Mill Theodore., Tebes-Stevens Caroline.   +23 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Impact of an Intervention on Plastics and Bioplastics on Pre-Service Science Teachers’ Green Chemistry and Sustainability Awareness and Their Attitudes Toward Environmental Education

Education Sciences
This research aimed to evaluate the awareness of pre-service science teachers regarding green chemistry, sustainability, and their perspectives on environmental education.
Ahmad Basheer, Ozcan Gulacar, Ayshi Sindiani, Ingo Eilks   +3 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source