Results 71 to 80 of about 11,608,149 (298)

Implementing innovations in chemistry learning and sustainability education in a non-formal student laboratory context

LUMAT, 2015
Informal and non-formal science education became major trends in many countries in recent years. Non-formal learning was suggested to help closing gaps in science education, e.g.
Nicole Garner, Antje Siol, Johannes Huwer, Rolf Hellman Rolf Hempelmann, Ingo Eilks   +4 more
doaj   +1 more source

GREEN CHEMISTRY EDUCATION

Problems of Education in the 21st Century
Green chemistry can also be referred to as sustainable chemistry and it is the design of chemical products and processes aimed at less or less the use of hazardous substances. It's about lessening the destructive consequences on the environment and the earth's sustainability (Wale et al., 2023; Mane et al., 2023). This accommodates many principles that
openaire   +1 more source

Chemistry Education for Climate Empowerment and Action

Urgent action is needed across the world to combat climate change and its impact on the social, economic, and environmental well-being of humans and the planet.
Wissinger, Jane E, Hurst, Glenn A, Quiroz-Martínez, Denise   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A unified strategy toward total syntheses of lindenane sesquiterpenoid [4 + 2] dimers

Nature Communications, 2019
Of the 3 classes of dimeric lindenane sesquiterpenoids, only type I And II have been targeted in total synthesis. Here, the authors report a unified strategy to synthetically access the 3 classes of lindenane sesquiterpenoids dimers by developing a [4 ...
Biao Du, Zhengsong Huang, Xiao Wang, Ting Chen, Guo Shen, Shaomin Fu, Bo Liu   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Aza-[4 + 2]-cycloaddition of benzocyclobutenones into isoquinolinone derivatives enabled by photoinduced regio-specific C–C bond cleavage

Nature Communications
The activation of C−C bond of benzocyclobutenones under mild reaction conditions remains a challenge. We herein report a photoinduced catalyst-free regio-specific C1−C8 bond cleavage of benzocyclobutenones, enabling the generation of versatile ortho ...
Liangkun Yang, Shiyang Li, Lichao Ning, Hansen Zhao, Liang Zhou, Weidi Cao, Xiaoming Feng   +6 more
doaj   +1 more source

Simple and Effective Integration of Green Chemistry and Sustainability Education into an Existing Organic Chemistry Course

, 2018
Green chemistry and sustainable development have become increasingly important topics for the education of future chemists. The cross-disciplinary nature of green chemistry and sustainable development often means these subjects are taught in conjunction ...
Brian J. J. Timmer, Johan Franzén, Timmer, Brian,, Ramström, Olof,, Dinér, Peter,, Olof Ramström, Peter Dinér, Daniel Hammarberg, Hammarberg, Daniel,, Franzen, Johan.,, Schaufelberger, Fredrik,, Fredrik Schaufelberger   +11 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source