Results 51 to 60 of about 11,608,149 (298)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Skeletal editing of pyridines to aryldialdehydes
Nature CommunicationsElectron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process ...
Meixin Yan +14 more
doaj +1 more source
Arylcarboxylation of unactivated alkenes with CO2 via visible-light photoredox catalysis
Nature Communications, 2023 Photocatalytic carboxylation of alkenes with CO2 is a promising and sustainable strategy to synthesize high value-added carboxylic acids. However, it is challenging and rarely investigated for unactivated alkenes due to their low reactivities. Herein, we
Wei Zhang +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Green Map Flushing Meadow Queens NY
, 2005 A map of Flushing Meadows Corona Park in Queens, NY, site of two world fairs (1939 and 1964) currently home to a number of recreation facilities and green space.
Green Map System (Firm)
core +1 more source
Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons
Nature CommunicationsScaffold hopping is a key strategy in drug discovery. While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design.
Shun Li +15 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Biotechnology for Biofuels, 2021 Background Production of biodiesel from renewable sources such as inedible vegetable oils by enzymatic catalysis has been a hotspot but remains a challenge on the efficient use of an enzyme.
Zi-Wen Zhou +7 more
doaj +1 more source
Role of Green Chemistry in Building Ethics Education
Jurnal Penelitian Pendidikan IPAThis is very important in growing students' environmental awareness through integrating green chemistry in learning as one of the efforts to protect the environment and reduce environmental pollution. Chemistry learning through green chemistry education has great potential in developing ethics as a method for solving environmental problems.
Mamluaturrahmatika, Annisa +2 more
openaire +1 more source