Results 81 to 90 of about 12,534,618 (262)

Enantioselective homologation of helical architectures from fluorenones to phenanthrenones with enhanced circular dichroism

Nature Communications
The development of efficient synthetic methods to access optically pure helical chiral molecules is a central challenge in organic chemistry due to their unique photophysical properties and potential applications in chiral photonic devices.
Shiyang Li, Shi Yan, Zhenzhong Liu, Yang Zhang, Yuqiao Zhou, Xiaoming Feng, Liang-Wen Feng, Xiaohua Liu   +7 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Metal–carbene-guided twofold cross-coupling of ethers with chromium catalysis

Nature Communications
Coupling by metal–carbene transfer enables the formation of several different bonds at the carbenoid site, enabling prochiral Csp 3 centers that are fundamental three-dimensional substructures for medicines to be forged with increased efficiency. However,
Fei Fan, Yong Peng, Xiaoyu Zhang, Sha Wang, Zheng Luo, Meiming Luo, Xiaoming Zeng   +6 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Green chemical processes: developments in research and education Green chemical processing ;, vol. 2./ edited by Mark Anthony Benvenuto.

, 2017
Collection of articles previously published in the journal Physical sciences reviews.In English.Includes bibliographical references and index.The "greening" of industry processes - i.e., making them more sustainable - is a popular and often lucrative ...
Benvenuto (Mark Anthony),
core  

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Nature Communications, 2018
The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild ...
Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, Xiaoming Zeng   +4 more
doaj   +1 more source

The chemistry of education : a periodic relationship [PDF]

, 2003
xiii, 312 leaves ; 28 cm.The purpose and focus of this research is to examine a chemistry of education and to build a metacognitive bridge between the two disciplines, chemistry and education, through autobiographical narrative development of a ...
H-Duke, Michelle, University of Lethbridge. Faculty of Education   +1 more
core  

Analysis of Student Worksheet Needs in Green Chemistry Based Physics Chemistry Practicum [PDF]

Sustainability issues in chemistry laboratories are increasingly important to address, particularly because practicum activities often generate hazardous waste that can negatively affect both health and the environment.
Nabila Z Hanani, Fatma Aningsih, Hadeli M, Sanjaya, Rahmat Zikri, Chindy E Putri, Herliani, Firmalia, Irma Amelia, Fricila Sasqia   +8 more
core   +1 more source

Facilitating the transition to sustainable green chemistry [PDF]

, 2018
Sustainable green chemistry depends on technically feasible, cost-effective and socially acceptable decisions by regulators, industry and the wider community. The discipline needs to embrace a new suite of tools and train proponents in their use.
Karen Makuch, Kaveh Madani, Madani, Kaveh, Burgman, MA, Makuch, Karen, Tennant, Mike, Mike Tennant, Voulvoulis, N, Mark Burgman, Nikolaos Voulvoulis   +9 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source