Results 111 to 120 of about 3,517,243 (294)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

"Effect of p-aminosalicylic acid rare earth complex on aging resistance of natural rubber"

Hecheng xiangjiao gongye
Natural rubber (NR) vulcanizates were prepared using rare earth antioxidants, such as lanthanum aminosalicylate (PAS-La), cerium aminosalicylate (PAS-Ce), lanthanum and cerium aminosalicylate (PAS-La-Ce), and hindered phenolic antioxidant 2246 ...
"LIU Yong-gang1,2, HAO Wei2, LIU Zhao-gang2, WANG Xiao-li1, MA Sheng-mei1, ZHANG Shi-zhong1, ZHANG Feng-long1"
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Ron Green Sr. and Eleanor Green interview

, 2002
Bothell, Washington, United StatesThis interview of Ron and Eleanor Green took place at the Hannan House, Bothell, Washington, in July 2002.
Green, Ron Sr.; Green, Eleanor
core  

Tempering and modification of basic oxygen furnace slag with blast furnace slag: Mineral phase transformations and cementitious material enrichment mechanisms

Case Studies in Construction Materials
This study investigates the phase evolution and enrichment mechanism of the cementitious materials in a blend of blast furnace (BF) and basic oxygen furnace (BOF) slags.
Shuai Hao, Guoping Luo, Lin Wang, Shengli An, Yifan Chai, Wei Song   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Quantitative evaluation on AlN transformation and volatilization of chlorides and fluorides in pyrometallurgical treatment for aluminum dross

Journal of Materials Research and Technology
Reaction characteristics in pyrometallurgical treatment for aluminum dross were studied qualitatively and quantitatively by thermal analysis. The transformation of aluminum nitride (AlN), volatilization of chlorides and fluorides in two kinds of dross ...
Rongbin Li, Jingjing Zhong, Mingzhuang Xie, Zhiwei Huang, Hongliang Zhao, Fengqin Liu   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source