Results 131 to 140 of about 795,836 (302)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Extraction of proteins from green leaves

, 1961
RESP ...
G. N. Festenstein, Festenstein, G. N.
core   +1 more source

"Effect of lanthanum p-aminosalicylate on vulcanization characteristics of natural rubber"

Hecheng xiangjiao gongye
Lanthanum chloride and sodium p-aminosalicylate were used as raw materials to synthesize a new environmental-friendly accelerator lanthanum p-aminosalicylate (PAS-La) by precipitation method.
"LIU Yong-gang, HAO Wei, ZHANG Wen-tao, LIU Zhao-gang, HU Yan-hong, WU Jin-xiu, MA Rui-feng, DU Gui-fang"
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Synergistic treatment of blast furnace slag and basic oxygen furnace slag for efficient recovery of iron: Phase transformation and oxidation mechanisms

Journal of Materials Research and Technology
In light of the steel industry's rapid advancements, the availability of high-quality mineral resources is diminishing. Therefore, the recovery of iron from BOF slag is of great significance to the sustainability development.
Lan Huang, Shengli An, Fang Zhang, Jun Peng, Yuxin Chen, Xin Ping, Chunheng Liu   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Green extractions of bioactives from Vitis vinifera L. (cv. Aglianico) leaves: phenolic profile, antioxidant and anti-cholinesterase activity of extracts.

, 2018
Preceding researches shown that grape polyphenol compounds defend against oxidative stress, responsible for neurodegenerative diseases, cancer and diabetes [1, 2].
NOLE', MARIAROSARIA, Chiummiento Lucia, Faraone Immacolata, Gioia Daniele, Saluzzi Rosa, Di Stefano Maria Rosaria, Milella Luigi, Sinisgalli Chiara, Vassallo Antonio   +8 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Green extraction of secondary metabolites from plants: Obstacles, current status, and trends

Sustainable Chemistry for the Environment
There is a constant search for new extraction methods for secondary metabolites from plants to improve efficiency and reduce the process cost and waste.
Daniela Torres-Ortiz, Guadalupe García-Alcocer, Laura Cristina Berumen-Segura, Miriam Estévez   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source