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Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Ileocecal Lipoma as a Lead Point for Adult Ileocolic Intussusception: A Diagnostic Challenge. [PDF]

Case Rep Surg
Jha SK, Kafle S, Thakur AK.
europepmc   +1 more source

The assembly of tetrameric human L-lactate dehydrogenase is regulated by ionic strength, β-NADH binding, cyclic peptides, and long-chain dicarboxylates. [PDF]

Protein Sci
Stefan A, Gentilucci L, Barbiroli AG, Rossi V, Liao H, Di Stefano G, He T, Hochkoeppler A.   +7 more
europepmc   +1 more source

Serpin-driven green camouflage and NIR fluorescence in frogs. [PDF]

Sci Adv
Vignesh R, Vu T, Harvey G, Menozzi L, Delia J, White W, Lin P, Galatis E, Johnsen S, Yao J, Taboada C.   +10 more
europepmc   +1 more source

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Green Design Methods for Mass Customization

Applied Mechanics and Materials, 2014
With the wide application of MC (mass customization) in manufacturing which can deal with the customer diversification and their individual requirements, the traditional green design method could not meet the demand of product development any more. This paper summarized native and external achievements related to green design and MC, and proposed two ...
Zhi Yong Dai, Ming Hai Yuan, Shuo Cheng, Ai Min Ji   +3 more
openaire   +1 more source