Results 161 to 170 of about 45,745 (286)

The effect of water activity and temperature on the production of some mycotoxins

open access: yes, 1979
Preventing mold from growing and producing mycotoxins requires knowledge of the conditions under which each of the toxinogenic molds becomes active. In this investigation the relation between fungal growth and mycotoxin formation and the factors water ...
Northolt, M.D.
core  

Editorial: Sustainable postharvest management practices for fresh produce

open access: yesFrontiers in Sustainable Food Systems, 2023
Asanda Mditshwa   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Heat Extraction of Green Sand Mold

open access: yesTHE JOURNAL OF THE JAPAN FOUNDRYMEN'S SOCIETY, 1974
KATASHIMA, Saburō   +1 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

ANALISIS VARIASI KOMPOSISI FLY ASH DAN BENTONIT PADA PENGIKAT CETAKAN PASIR TERHADAP PERMEABILITAS, KEKUATAN TEKAN, DAN FLUIDITAS GREEN SAND MOLD

open access: yes, 2017
Abstrak. Penelitian ini bertujuan untuk menganalisis penggunaan fly ash sebagai campuran pengikat terhadap permeabilitas, kekuatan tekan dan fluiditas dengan bentuk pre-experimental model one-shot case study. Data diperoleh setelah Green sand mold diberi
Herwido, Novinda Tegar   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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