Results 111 to 120 of about 1,857,789 (295)

Molecularly imprinted polymers in solid-phase microextraction: Enhancing the analysis of pharmaceutical compounds across diverse sample matrices

Journal of Pharmaceutical and Biomedical Analysis Open
The biomedicine scientific field has made continuous progress, introducing various pharmaceutical compounds to enhance human life. While these advancements bring benefits, the unregulated use of these compounds raises concerns, particularly regarding ...
Rafael Oliveira Martins, Almir Custodio Batista Junior, Camila Cíntia Sousa Melo Brito, Yuri Arrates Rocha, Andréa Rodrigues Chaves   +4 more
doaj   +1 more source

Long-Term Testing and Properties of Acrylic for the Daya Bay Antineutrino Detectors

, 2012
The Daya Bay reactor antineutrino experiment has recently measured the neutrino mixing parameter sin22{\theta}13 by observing electron antineutrino disappearance over kilometer-scale baselines using six antineutrino detectors at near and far distances ...
Heeger, K. M., Krohn, M., Littlejohn, B. R.   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Towards Greener Sample Preparation: A Review on Micro-QuEChERS Advances and Applications in Food, Environmental, and Biological Matrices

Separations
This review provides a comprehensive evaluation of recent advances in miniaturized Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) sample preparation techniques applied across food, environmental, and biological matrices. Covering developments
Athina Papadopoulou, Vasiliki Boti, Christina Nannou   +2 more
doaj   +1 more source

Impacts of indoor surface finishes on bacterial viability. [PDF]

, 2019
Microbes in indoor environments are constantly being exposed to antimicrobial surface finishes. Many are rendered non-viable after spending extended periods of time under low-moisture, low-nutrient surface conditions, regardless of whether those surfaces
Ben Maamar, Sarah, Gilbert, Jack A, Glawe, Adam J, Gottel, Neil, Hartmann, Erica M, Hu, Jinglin   +5 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dysregulation of of phospholipid-specific phagocytosis by B1 B cells in diet-induced obese mice [PDF]

, 2016
B1 B cells have received increasing attention recently due to their newly discovered phagocytic and microbicidal capabilities. Several studies have demonstrated that B1 cells can phagocytize polystyrene fluorescent particles, bacteria (Staphylococcus ...
Vo, Hung
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Development of durable “green” concrete exposed to deicing chemicals via synergistic use of locally available recycled materials and multi-scale modifiers [PDF]

, 2018
From the economic and social perspectives, the use of waste materials would not be attractive until their costs and quality can satisfy the construction requirements.
Cui, Na, Xie, Ning
core