Results 101 to 110 of about 3,283,917 (297)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
, 2010 Recent developments suggest that the near-region of rotating black holes behaves like a CFT. To understand this better, I propose to study quantum fields in this region.
Krishnan, Chethan
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Green space: A natural high [PDF]
Nature, 2016 Exposure to nature makes people happy and could cut mental-health inequalities between the rich and poor.
openaire +2 more sources
How Do Homebuyers Value Different Types of Green Space? [PDF]
It is important to understand tradeoffs in preferences for natural and constructed green space in semi-arid urban areas because these lands compete for scarce water resources.
Bark, Rosalind H. +3 more
core +1 more source
Stability of Covariant Relativistic Quantum Theory
, 2004 In this paper we study the relativistic quantum mechanical interpretation of the solution of the inhomogeneous Euclidean Bethe-Salpeter equation. Our goal is to determine conditions on the input to the Euclidean Bethe-Salpeter equation so the solution ...
Polyzou, Wayne, Wessels, Victor
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Superstring action in AdS_5 x S^5: kappa symmetry light cone gauge
, 2000 As part of program to quantize superstrings in AdS_5 x S^5 background in light cone approach we find the explicit form of the corresponding Green-Schwarz action in fermionic light-cone kappa-symmetry gauge.
A. A. Tseytlin +54 more
core +1 more source