Results 61 to 70 of about 16,319 (268)
Land, 2014 Values associated with scenic beauty are common “pull factors” for amenity migrants, however the specific landscape features that attract amenity migration are poorly understood.
Jelena Vukomanovic, Barron J. Orr
doaj +1 more source
International Journal of Digital Earth, 2020 The presence of green spaces within city centres has been recognized as a valuable component of the city landscape. Vegetation provides a variety of benefits including energy saving, improved air quality, reduced noise pollution, decreased ambient ...
Christina Corbane +9 more
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"The Greens" and "Green Fire" [PDF]
Pacific Conservation Biology, 1997 "The Greens", written by Bob Brown and Peter Singer introduces the Greens to a wide audience. Both authors were Green candidates for the Australian Senate at the time of writing. Bob Brown is one of the founders of the Australian Greens. As director of the Tasmanian Wilderness Society, he led the campaign that saved the Franklin River from impoundment ...
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Environmental Research: HealthResidential greenness has been associated with improved renal function, whereas traffic-related air pollutants such as PM _2 . _5 and NO _2 have been linked to declines in renal function. However, their interrelationship remains unclear.
Chia-Fang Wu +12 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
MedicinaBackground and Objectives: Revumenib (SNDX-5613) is a powerful and specific inhibitor of the menin–KMT2A binding interaction. It is a small molecule that is currently being researched to treat KMT2A-rearranged (KMT2Ar) acute leukemias.
Mohamed W. Attwa +2 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source