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GRKs as Modulators of Neurotransmitter Receptors [PDF]
Cells, 2020 Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich +1 more
doaj +3 more sources
Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots [PDF]
International Journal of Molecular Sciences, 2021 G protein-coupled receptors (GPCRs) are regulated by GPCR kinases (GRKs) which phosphorylate intracellular domains of the active receptor. This results in the recruitment of arrestins, leading to desensitization and internalization of the GPCR. Aside from acting on GPCRs, GRKs regulate a variety of membrane, cytosolic, and nuclear proteins not only via
Mona Reichel +4 more
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GRK et arrestines : la piste thérapeutique ? [PDF]
médecine/sciences, 2006 La phosphorylation d’un recepteur couple aux proteines G (RCPG) par une kinase specifique, nommee GRK (G protein-coupled receptor kinase), est une premiere etape qui participe, avec l’action des arrestines, a l’arret de la transmission du signal, au cours d’un processus appele desensibilisation.
Métayé, Thierry +2 more
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The Roles of GRKs in Hemostasis and Thrombosis [PDF]
International Journal of Molecular Sciences, 2020 Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these
Xi Chen +3 more
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Frontiers in Immunology, 2022 G-protein coupled receptor kinases (GRKs) participate in the regulation of chemokine receptors by mediating receptor desensitization. They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their intracellular ...
Katharina M. Glaser +4 more
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G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. [PDF]
, 2017 G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Aryal, Dipendra K. +5 more
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Rational Cohomology Algebra of Mapping Spaces between Complex Grassmannians
International Journal of Mathematics and Mathematical Sciences, 2020 We consider the complex Grassmannian Grk,n of k-dimensional subspaces of ℂn. There is a natural inclusion in,r:Grk,n↪Grk,n+r. Here, we use Sullivan models to compute the rational cohomology algebra of the component of the inclusion in,r in the space of ...
Paul Antony Otieno +2 more
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GRK 26: Herodotus and Thucydides [PDF]
, 2017 Syllabus and bibliography for an advanced Greek seminar taught at Dartmouth in Winter ...
Michael Lurie
core +1 more source