Results 31 to 40 of about 35,246 (224)

GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation

Nature Communications, 2022
GPCR kinases (GRKs) regulate GPCR interactions and thus functions. Here, the authors report a comprehensive panel of GRK knockout cells, used to assess the GRK-specific β-arrestin recruitment. Selective engagement of GRKs induces distinct GPCR–β-arrestin
J. Drube, R. S. Haider, E. S. F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, J. Filor, V. Weitzel, A. Kliewer, E. Miess-Tanneberg, E. Kostenis, S. Schulz, C. Hoffmann   +15 more
doaj   +1 more source

The GRKs Reactome: Role in Cell Biology and Pathology [PDF]

International Journal of Molecular Sciences, 2021
G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mechanisms of GRK expression, its alternation, and their ...
Chaudhary, Preeti Kumari, Kim, Soochong
openaire   +2 more sources

Intravesical Bladder Treatment and Deep Learning Applications to Improve Irritative Voiding Symptoms Caused by Interstitial Cystitis: A Literature Review [PDF]

International Neurourology Journal, 2023
Our comprehension of interstitial cystitis/painful bladder syndrome (IC/PBS) has evolved over time. The term painful bladder syndrome, preferred by the International Continence Society, is characterized as “a syndrome marked by suprapubic pain during ...
Yongwon Cho, Seunghyun Youn
doaj   +1 more source

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper, AB Singleton, AD Gitler, B Rogina, C Hertzman, CD Link, E Berezikov, E Cuppen, EA Nollen, Ellen A. A. Nollen, GM Halliday, HA Tissenbaum, HG van, HH Liou, HM Beere, JF Morley, Karen L. Thijssen, L Chen, M Kaeberlein, M Kaeberlein, M Nishimura, M Viswanathan, MC Chartier-Harlin, MG Spillantini, MG Spillantini, MH Polymeropoulos, NB Cole, PK Auluck, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, S Kim, S Miksys, S Roy, S Willingham, Stuart K. Kim, T Kai, TF Outeiro, Tjakko J. van Ham   +38 more
core   +8 more sources

Peningkatan Kualitas Penghitungan Emisi Gas Rumah Kaca dari Sektor Pengelolaan Sampah dengan Metode IPCC 2006 (Studi Kasus: Kota Cilacap)

Jurnal Ilmu Lingkungan, 2020
Gas rumah kaca (GRK) berpotensi diemisikan dari berbagai tahapan dalam pengelolaan sampah, termasuk dari tahap penanganan sampah di sumber, pengangkutan dan penimbunan sampah di tempat pemrosesan akhir (TPA).
Mochammad Chaerul, Arry Febrianto, Haryo Satriyo Tomo   +2 more
doaj   +1 more source

GRKs and arrestins: regulators of migration and inflammation [PDF]

Journal of Leukocyte Biology, 2006
AbstractIn the immune system, signaling by G protein-coupled receptors (GPCRs) is crucial for the activity of multiple mediators, including chemokines, leukotrienes, and neurotransmitters. GPCR kinases (GRKs) and arrestins control GPCR signaling by mediating desensitization and thus, regulating further signal propagation through G proteins.
Anne, Vroon, Cobi J, Heijnen, Annemieke, Kavelaars   +2 more
openaire   +2 more sources

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Andresen, Bradley T., Bastepe, Murat, Blessing, Christopher P., Erickson, Catherine E., Gul, Rukhsana, Holowka, David, Jackson, Edwin K., Liu, Tammy, Nguyen, Jenny, Pulakat, Lakshmi   +9 more
core   +3 more sources

The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
G protein-coupled receptor kinases (GRKs) and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent GPCR desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR.
Ribas, Catalina, Penela, Petronila, Murga, Cristina, Salcedo, Alicia, García-Hoz, Carlota, Jurado-Pueyo, María, Aymerich, Ivette, Mayor, Federico   +7 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Kajian Jejak Karbon dari Aktivitas Kampus Fakultas Ekonomika dan Bisnis Universitas Diponegoro [PDF]

, 2017
Jejak karbon merupakan keseluruhan emisi GRK yang disebabkan secara langsung atau tidak langsung dari sebuah proses produksi, organisasi atau individu.
M, D. A. (Dian), Samadikun, B. P. (Budi), Wardhana, I. W. (Irawan)   +2 more
core