Results 1 to 10 of about 29,598 (207)

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome [PDF]

Nature Communications
The bacterial chaperonin GroEL/ES promotes protein folding post-translation by transiently encapsulating client proteins within a central chamber. GroEL also binds translating ribosomes in vivo, implying an additional role in cotranslational folding ...
Alžběta Roeselová, Sarah L. Maslen, Jessica Zhiyun He, Gabija Jurkeviciute, Aleksandra Pajak, J. Mark Skehel, Radoslav I. Enchev, David Balchin   +7 more
doaj   +2 more sources

Phage Display Selection and In Silico Characterization of Peptides as Potential GroEL Modulators [PDF]

Pharmaceutics
Background/Objectives. Antibiotic resistance is an escalating global health concern, highlighting the need for innovative antibacterial strategies beyond traditional drugs.
Stefania Olla, Stella Garcia Colombarolli, Chiara Siguri, Davide Murrau, Alberto Vitali   +4 more
doaj   +2 more sources

Targeted protein degradation in Escherichia coli using CLIPPERs [PDF]

EMBO Reports
New, universal tools for targeted protein degradation in bacteria can help to accelerate protein function studies and antimicrobial research. We describe a new method for degrading bacterial proteins using plasmid-encoded degrader peptides which deliver ...
Matylda Anna Izert-Nowakowska, Maria Magdalena Klimecka, Anna Antosiewicz, Karol Wróblewski, Jakub Józef Kowalski, Katarzyna Justyna Bandyra, Tomasz Góral, Sebastian Kmiecik, Remigiusz Adam Serwa, Maria Wiktoria Górna   +9 more
doaj   +2 more sources

Роль білків теплового шоку в прогнозуванні перебігу клімактеричного синдрому

Український журнал Здоров'я жінки, 2022
Проблема клімактерію актуальна вже протягом багатьох десятиліть. Патогенетично обґрунтованим методом лікування, враховуючи зміну гормонального фону жінки, є замісна гормональна терапія.
I.V. Sokol, D.O. Govsieiev
doaj   +1 more source

Prospective study to estimate the role of different infertility factors in prediction of unsuccessful IVF outcome

Репродуктивная эндокринология, 2021
Research objective: in a prospective controlled study to investigate the role of HSP60, GroEl and other infertility factors as predictors of successful IVF outcome. Materials and methods.
V.O. Berestovyi, A. Mahmood, A.M. Martych, A.B. Prylutska, O.O. Berestovyi, D.O. Govsieiev   +5 more
doaj   +1 more source

Роль ендокринних факторів та маркерів клітинного стресу у прогнозуванні ефективності лікування клімактеричного синдрому в період перименопаузи

Український журнал Здоров'я жінки, 2022
Жiнки клiмактеричнoгo вiку становлять 10% популяції Землі, і наразі проблема патологічного клімактерію залишається актуальною. Причиною розвитку клімактерію вважається дефіцит естрогенів, тому використання замісної терапії є патогенетично обґрунтованим ...
I.V. Sokol, D.O. Govsieiev
doaj   +1 more source

Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice

Gut Microbes, 2021
Gut microbiota and the immune system are in constant exchange shaping both host immunity and microbial communities. Here, improper immune regulation can cause inflammatory bowel disease (IBD) and colitis. Antibody therapies blocking signaling through the
Verena Friedrich, Ignasi Forné, Dana Matzek, Diana Ring, Bastian Popper, Lara Jochum, Stefanie Spriewald, Tobias Straub, Axel Imhof, Anne Krug, Bärbel Stecher, Thomas Brocker   +11 more
doaj   +1 more source

Probing the dynamic process of encapsulation in Escherichia coli GroEL. [PDF]

PLoS ONE, 2013
Kinetic analyses of GroE-assisted folding provide a dynamic sequence of molecular events that underlie chaperonin function. We used stopped-flow analysis of various fluorescent GroEL mutants to obtain details regarding the sequence of events that ...
Toshifumi Mizuta, Kasumi Ando, Tatsuya Uemura, Yasushi Kawata, Tomohiro Mizobata   +4 more
doaj   +1 more source

Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response [PDF]

, 2013
Devon Kavanaugh is in receipt of a Teagasc Walsh Fellowship. The authors would also like to acknowledge the support of Science Foundation Ireland under Grant No.
Butto, Ludovica F., Clyne, Marguerite, Hickey, Rita M., Joshi, Lokesh, Kane, Marian, Kavanaugh, Devon W., Lane, Jonathan, O'Callaghan, John, Slattery, Helen   +8 more
core   +10 more sources

Characterization of Molecular Chaperone GroEL as a Potential Virulence Factor in Cronobacter sakazakii

Foods, 2023
The molecular chaperone GroEL of C. sakazakii, a highly conserved protein encoded by the gene grol, has the basic function of responding to heat shock, thus enhancing the bacterium’s adaptation to dry and high-temperature environments, which poses a ...
Dongdong Zhu, Yufei Fan, Xiaoyi Wang, Ping Li, Yaping Huang, Jingbo Jiao, Chumin Zhao, Yue Li, Shuo Wang, Xinjun Du   +9 more
doaj   +1 more source