Results 81 to 90 of about 30,272 (208)

AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.
ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick, Audrey Morasse, Melanie Leclerc, Ziying Liu, Qing Yan Liu, Sonia Leclerc, Milica Momcilovic, Annie Viau, Amine A. Kamen   +8 more
wiley   +1 more source

Immunization using GroEL decreases Clostridium difficile intestinal colonization. [PDF]

PLoS ONE, 2013
Clostridium difficile is a pathogen which is responsible for diarrhea and colitis, particularly after treatment with antibiotics. Clinical signs are mainly due to two toxins, TcdA and TcdB.
Séverine Péchiné, Claire Hennequin, Céline Boursier, Sandra Hoys, Anne Collignon   +4 more
doaj   +1 more source

Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin, Moeka Sasazawa, James Byrnes, Mark E. Bowen   +3 more
wiley   +1 more source

DnaK Functions as a Central Hub in the E. coli Chaperone Network

Cell Reports, 2012
Cellular chaperone networks prevent potentially toxic protein aggregation and ensure proteome integrity. Here, we used Escherichia coli as a model to understand the organization of these networks, focusing on the cooperation of the DnaK system with the ...
Giulia Calloni, Taotao Chen, Sonya M. Schermann, Hung-chun Chang, Pierre Genevaux, Federico Agostini, Gian Gaetano Tartaglia, Manajit Hayer-Hartl, F. Ulrich Hartl   +8 more
doaj   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review [PDF]

, 2011
During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here we review the links between disordered proteins and the associated networks, and describe the consequences of local, mesoscopic and global ...
Daniel V. Veres, Eszter Hazai, Federico Miozzo, Francesco Piazza, Huba J. M. Kiss, Kuljeet Singh Sandhu, Peter Csermely, Ruth Nussinov, Zsolt Hoksza   +8 more
core   +4 more sources

Detection and Genetic Diversity of Heritable Bacterial Symbionts in Human Lice Based on 16S‐rRNA Gene

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Candidatus Riesia pediculicola and Wolbachia were found in 79.6% and 95.2% of head lice, and 81.8% and 100% of body lice. Candidatus Riesia pthiripubis and Wolbachia appeared in 41.7% and 75% of pubic lice. Maximum‐likelihood 16S‐rRNA phylogeny revealed substantial heterogeneity within symbiont populations. ABSTRACT Human lice are obligate bloodsucking
Anthony Marteau, Sophie Brun, Arezki Izri, Mohammad Akhoundi   +3 more
wiley   +1 more source

Protective Effect of Recombinant Proteins of Cronobacter Sakazakii During Pregnancy on the Offspring

Frontiers in Cellular and Infection Microbiology, 2020
Cronobacter sakazakii is a food-borne pathogen carried in milk powder that can cause severe bacteremia, enterocolitis, and meningitis in newborns, which can lead to death of newborns.
Jia-rong Song, Yan-wen Fu, Ping Li, Ting Du, Xin-jun Du, Shuo Wang, Shuo Wang   +6 more
doaj   +1 more source

Conformational Dynamics of Supramolecular Protein Assemblies in the EMDB [PDF]

, 2010
The Electron Microscopy Data Bank (EMDB) is a rapidly growing repository for the dissemination of structural data from single-particle reconstructions of supramolecular protein assemblies including motors, chaperones, cytoskeletal assemblies, and viral ...
Bathe, Mark, Kim, Do-Nyun, Nguyen, Cong-Tri   +2 more
core   +2 more sources

Exploring the Potential and Evaluating Hydrocarbon Degradation by Novel Antarctic Dietzia and Pusillimonas Isolates From a Pristine Environment

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
The Antarctic Dietzia and Pusillimonas isolates were tested for bioremediation applications. Genomic analyses revealed the potential to degrade complex organic compounds, potential virulence factors and resistance genes. Physiological assays showed a wide range of adaptation to abiotic factors and sensitivity to different groups of antibiotics ...
Tomasz Krucoń, Julia Karbowska, Wiktoria Pietrowicz, Robert Stasiuk, Łukasz Drewniak   +4 more
wiley   +1 more source