Results 81 to 90 of about 29,598 (207)

Revealing taxonomy, activity, and substrate assimilation in mixed bacterial communities by GroEL-proteotyping-based stable isotope probing

iScience
Summary: Protein-based stable isotope probing (protein-SIP) can link microbial taxa to substrate assimilation. Traditionally, protein-SIP requires a sample-specific metagenome-derived database for samples with unknown composition. Here, we describe GroEL-
Simon Klaes, Shobhit Madan, Darja Deobald, Myriel Cooper, Lorenz Adrian   +4 more
doaj   +1 more source

Comparative genomic analysis of two Chilean Renibacterium salmoninarum isolates and the type strain ATCC 33209T [PDF]

, 2018
Indexación: Scopus.Two previously characterized Chilean isolates (H-2 and DJ2R), obtained from cage-cultured Atlantic salmon with clinical signs of bacterial kidney disease in southern Chile, were used (Bethke et al. 2016, 2017).
Avendaño-Herrera, R., Bethke, J., Yáñez, A.J.   +2 more
core   +1 more source

GroEL Binds Artificial Proteins with Random Sequences [PDF]

Journal of Biological Chemistry, 2000
Chaperonin GroEL from Escherichia coli binds to the non-native states of many unrelated proteins, and GroEL-recognizable structural features have been argued. As model substrate proteins of GroEL, we used seven artificial proteins (138 approximately 141 residues), each of which has a unique but randomly chosen amino acid sequence and no propensity to ...
Katsuhiko Aoki, Fumihiro Motojima, Hideki Taguchi, Tetsuya Yomo, Masasuke Yoshida   +4 more
openaire   +2 more sources

Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga, Paige A. Wolverson, Mark O. Collins, Oliver Heaney, Joby Cole, Luke R. Green, Jonathan G. Shaw   +6 more
wiley   +1 more source

Immunization using GroEL decreases Clostridium difficile intestinal colonization. [PDF]

PLoS ONE, 2013
Clostridium difficile is a pathogen which is responsible for diarrhea and colitis, particularly after treatment with antibiotics. Clinical signs are mainly due to two toxins, TcdA and TcdB.
Séverine Péchiné, Claire Hennequin, Céline Boursier, Sandra Hoys, Anne Collignon   +4 more
doaj   +1 more source

Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]

, 2013
Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter, Nussinov, Ruth, Szilágyi, András   +2 more
core   +2 more sources

Assessment of the Incidence of Vibrio spp. in Shrimp Farms Relative to Water Parameters and Their Molecular Detection in the Southwest Coastal Region of Bangladesh

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
There was no significant relation between the incidence of Vibrio spp. and water parameters, except ammonium in the winter season. In this study, 48.02% (85/177) isolates were positive for Vibrio cholerae, 51.97% (92/177) for Vibrio parahaemolyticus, 15.21% (14/92) for trh gene, and 6.52% (6/92) for tdh gene.
M. Sohidullah, Bidyut Matubber, Md. Hamidur Rahman, Abu Sayeed, Sadia Rahman, Linta Yesmin, Md. Jannat Hossain, Md. Imran Chowdhury, Muhammad Ashiqul Alam   +8 more
wiley   +1 more source

DnaK Functions as a Central Hub in the E. coli Chaperone Network

Cell Reports, 2012
Cellular chaperone networks prevent potentially toxic protein aggregation and ensure proteome integrity. Here, we used Escherichia coli as a model to understand the organization of these networks, focusing on the cooperation of the DnaK system with the ...
Giulia Calloni, Taotao Chen, Sonya M. Schermann, Hung-chun Chang, Pierre Genevaux, Federico Agostini, Gian Gaetano Tartaglia, Manajit Hayer-Hartl, F. Ulrich Hartl   +8 more
doaj   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source