Results 51 to 60 of about 108,974 (263)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ground-Ice Wedges: The Dominant Form of Ground-Ice on the North Coast of Alaska [PDF]

The Journal of Geology, 1915
It is a widely known fact that the ground in Arctic and subArctic regions is permanently frozen to a great depth, only the upper few feet thawing in summer. Nearly all observers have reported the presence of bodies of more or less clear ice underlying the surface of the ground, usually immediately below the limit of annual thawing.
openaire   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Isotopic composition on ground ice in Western Yamal (Marre-Sale)

Лëд и снег, 2015
The profile of Quaternary sediments near Marre-Salle polar station, Western Yamal Peninsula, has large bodies of tabular ground ice. This profile is considered strata-typical and critical in understanding of paleogeographic conditions of the Arctic in ...
I. D. Streletskaya, A. A. Vasiliev, G. E. Oblogov, A. G. Matyukhin   +3 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Dissolved organic carbon (DOC) in Arctic ground ice [PDF]

The Cryosphere, 2015
Thermal permafrost degradation and coastal erosion in the Arctic remobilize substantial amounts of organic carbon (OC) and nutrients which have accumulated in late Pleistocene and Holocene unconsolidated deposits.
M. Fritz, T. Opel, G. Tanski, U. Herzschuh, H. Meyer, A. Eulenburg, H. Lantuit   +6 more
doaj   +1 more source

Ground ice map of Canada

, 2020
This Open File presents new national-scale mapping of ground ice conditions in Canada. The mapping depicts a first-order estimate of the combined volumetric percentage of excess ice in the top 5 m of permafrost from segregated, wedge, and relict ice. The estimates for the three ice types are based on modelling by O'Neill et al.
H B O'Neill, S A Wolfe, C Duchesne
openaire   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

The ground ice melting has accelerated the lake expansion in the hinterland of the permafrost region on the Qinghai-Tibet Plateau

Journal of Hydrology: Regional Studies
Study region: The Zonag Lake-Yanhu Lake basin on the Qinghai-Tibet Plateau (QTP). Study focus: The melting of ground ice near the permafrost table is an important factor leading to the lake expansion on the QTP.
Shibo Liu, Huayun Zhou, Lin Zhao, Lingxiao Wang, Defu Zou, Guojie Hu, Yuxin Zhang, Zhe Sun, Zhibin Li, Yongping Qiao   +9 more
doaj   +1 more source

Twenty-four buried ice masses remotely mapped in Transantarctic Mountains, Antarctica

Geocarto International, 2023
Glacial ice contains information on paleoclimate, but typically is less than 1 Myrs old because glaciers continuously flow and melt. A recently discovered buried ice mass in Antarctica is dated to 3-5 Myrs and highlights the potential for long ...
Jaakko Putkonen, Taufique H. Mahmood
doaj   +1 more source