Results 61 to 70 of about 962,375 (304)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Effect of surficial geology mapping scale on modelled ground ice in Canadian Shield terrain [PDF]
The CryosphereGround ice maps at small scales offer generalized depictions of abundance across broad circumpolar regions. In this paper, the effect of surficial geology mapping scale on modelled ground ice abundance is examined in the Slave Geological Province of the ...
H. B. O'Neill +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
GeosciencesClimate-induced changes contribute to the thawing of ice-rich permafrost in the Arctic, which leads to the release of large amounts of organic carbon into the atmosphere in the form of greenhouse gases, mainly carbon dioxide and methane.
Petr Semenov +11 more
doaj +1 more source
Orbital ice: an exact Coulomb phase on the diamond lattice
, 2011 We demonstrate the existence of orbital Coulomb phase as the exact ground state of p-orbital exchange Hamiltonian on the diamond lattice. The Coulomb phase is an emergent state characterized by algebraic dipolar correlations and a gauge structure ...
Congjun Wu +2 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Dissolved organic carbon (DOC) in Arctic ground ice [PDF]
The Cryosphere, 2015 Thermal permafrost degradation and coastal erosion in the Arctic remobilize substantial amounts of organic carbon (OC) and nutrients which have accumulated in late Pleistocene and Holocene unconsolidated deposits.
M. Fritz +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Isotopic composition on ground ice in Western Yamal (Marre-Sale)
Лëд и снег, 2015 The profile of Quaternary sediments near Marre-Salle polar station, Western Yamal Peninsula, has large bodies of tabular ground ice. This profile is considered strata-typical and critical in understanding of paleogeographic conditions of the Arctic in ...
I. D. Streletskaya +3 more
doaj +1 more source
Twenty-four buried ice masses remotely mapped in Transantarctic Mountains, Antarctica
Geocarto International, 2023 Glacial ice contains information on paleoclimate, but typically is less than 1 Myrs old because glaciers continuously flow and melt. A recently discovered buried ice mass in Antarctica is dated to 3-5 Myrs and highlights the potential for long ...
Jaakko Putkonen, Taufique H. Mahmood
doaj +1 more source