Results 71 to 80 of about 1,381,165 (330)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Ground-Motion Intensity Measures for the Seismic Response of the Roof-Isolated Large-Span Structure

Buildings
Ground-motion intensity measures (IMs), which quantify and describe the characteristics of earthquake ground motion, are of utmost importance in the assessment of seismic risk and the design of resilient structures with large spans.
Wei Zhen, Yikun Qiu, Yanhua Zhang, Wei Li   +3 more
doaj   +1 more source

Intelligent Adaptive Motion Control for Ground Wheeled Vehicles [PDF]

, 2014
In this paper a new intelligent adaptive control is applied to solve a problem of motion control of ground vehicles with two independent wheels actuated by a differential drive.
MELLUSO, Maurizio
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Seismic Response of a Tall Building to Recorded and Simulated Ground Motions [PDF]

, 2014
Seismological modeling technologies are advancing to the stage of enabling fundamental simulation of earthquake fault ruptures, which offer new opportunities to simulate extreme ground motions for collapse safety assessment and earthquake scenarios for ...
Bijelic, Nenad, Deierlein, Gregory, Lin, Ting   +2 more
core   +1 more source

Statistical modeling of ground motion relations for seismic hazard analysis

, 2013
We introduce a new approach for ground motion relations (GMR) in the probabilistic seismic hazard analysis (PSHA), being influenced by the extreme value theory of mathematical statistics. Therein, we understand a GMR as a random function.
B Efron, BV Gnedenko, CA Cornell, CB Crouse, CM Montgomery, D Enescu, D Giardini, D Stromeyer, DA Rhoades, DD Mari, DJ Dupuis, E Kalkan, F Scherbaum, FO Strasser, FO Strasser, GL Molas, GM Atkinson, GM Atkinson, GM Atkinson, J Beirlant, J Douglas, J Douglas, J Hüsler, JC Stepp, JG Anderson, JJ Bommer, JJ Bommer, JJ Bommer, K Beyer, K Campbell, K Sadigh, KW Campbell, L Al Atik, L Haan de, L Huyse, L Landry, LF Restrepo-Velez, M Falk, M Massa, M Raschke, M Raschke, M Raschke, M Raschke, M Sørensen, Mathias Raschke, MH Quenouille, MR Leadbetter, N Abrahamson, N Abrahamson, N Morikawa, NA Abrahamson, NA Abrahamson, NN Ambraseys, NN Ambraseys, NN Ambraseys, NN Ambraseys, P Billingsley, P Cosentino, P Spudich, PJ Stafford, PS Lin, RA Fisher, RK McGuire, RK McGuire, RL Smith, RR Youngs, S Castellaro, S Coles, T Chang, T Utsu, WB Joyner, WB Joyner, Y-H Chen, Z Kabluchko   +73 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Steady Motion of a Rigid Disk of Finite Thickness on a Horizontal Plane

, 2005
The article discusses the steady motion of a rigid disk of finite thickness rolling on its edge on a horizontal plane under the influence of gravity. The governing equations are presented and two cases allowing for a steady state solution are considered:
Appell, Borisov, Kessler, Kuleshov, Kuleshov, Le Saux, MacMillan, Milan Batista, Milne, Moffatt, O’Reilly, Paris, Routh, Routh, Seydel, Synge, Thomson, Webster   +17 more
core   +1 more source

Simulation Studies of the NLC with Improved Ground Motion Models [PDF]

, 2000
The performance of various systems of the Next Linear Collider (NLC) have been studied in terms of ground motion using recently developed models. In particular, the performance of the beam delivery system is discussed.
Hendrickson, L., Raimondi, P., Raubenheimer, T., Seryi, A., Tenenbaum, P.   +4 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source