Results 71 to 80 of about 1,486,491 (293)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Enhanced low-temperature entropy and flat-band ferromagnetism in the t-J model on the sawtooth lattice

, 2007
Using the example of the sawtooth chain, we argue that the t-J model shares important features with the Hubbard model on highly frustrated lattices. The lowest single-fermion band is completely flat (for a specific choice of the hopping parameters $t_{i ...
Honecker, A., Richter, J.
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Ground State for the Schrödinger Operator with the Weighted Hardy Potential

International Journal of Differential Equations, 2011
We establish the existence of ground states on ℝ𝑁 for the Laplace operator involving the Hardy-type potential. This gives rise to the existence of the principal eigenfunctions for the Laplace operator involving weighted Hardy potentials. We also obtain a
J. Chabrowski, K. Tintarev
doaj   +1 more source

Hall effect in heavy-fermion metals

, 2012
The heavy fermion systems present a unique platform in which strong electronic correlations give rise to a host of novel, and often competing, electronic and magnetic ground states.
Friedemann, S., Nair, Sunil, Schofield, A. J., Si, Q., Steglich, F., Wirth, S.   +5 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Anomalous Fluctuations of Directed Polymers in Random Media

, 1993
A systematic analysis of large scale fluctuations in the low temperature pinned phase of a directed polymer in a random potential is described. These fluctuations come from rare regions with nearly degenerate ``ground states''.
A. J. McKane, B. Derrida, B. Derrida, C. A. Doty, D. A. Huse, D. A. Huse, D. Forster, D. J. Amit, D. S. Fisher, D. S. Fisher, D. S. Fisher, D. S. Fisher, Daniel S. Fisher, E. Medina, G. Parisi, H. K. Janssen, H. K. Janssen, H. van Biejeren, J. Krug, J. M. Kim, J. P. Bouchaud, J. P. Bouchaud, J. P. Bouchaud, J. Z. Imbrie, K. Binder, L. Balents, L. Ioffe, L. P. Kadanoff, M. Kardar, M. Kardar, M. Kardar, M. Mézard, M. Mézard, M. Mézard, M. V. Feigel'man, O. Narayan, P. Bak, P. Bak, P. C. Martin, T. Halpin-Healy, T. Hwa, T. Hwa, Terence Hwa, U. Schulz, Y. Imry, Y.-C. Zhang, Z. Olami   +46 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

General Neutralino NLSPs at the Early LHC

, 2011
Gauge mediated supersymmetry breaking (GMSB) is a theoretically well-motivated framework with rich and varied collider phenomenology. In this paper, we study the Tevatron limits and LHC discovery potential for a wide class of GMSB scenarios in which the ...
A Abulencia, A Abulencia, A Katz, A Katz, A Rajaraman, AM Thalapillil, David Shih, DS Alves, E Nakamura, G Aad, G Aad, G Giudice, H Baer, H Baer, H Baer, J Alwall, J Alwall, J Alwall, J Jaeckel, J Jaeckel, J Thaler, JM Campbell, Joshua T. Ruderman, JT Ruderman, KT Matchev, M Buican, M Dine, M Dine, M Dine, M Muhlleitner, P Meade, P Meade, P Meade, S Abel, S Abel, S Ambrosanio, S Chatrchyan, S Chatrchyan, S Dimopoulos, S Dimopoulos, S Dimopoulos, S Dube, SP Martin, T Junk, T Sjöstrand, V Abazov, V Khachatryan, VM Abazov, W Beenakker, W Beenakker   +49 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source