Results 51 to 60 of about 4,426,015 (295)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Ground Settlement Characteristics and Influencing Factors of Metro Shield Tunneling in Tianjin Soft Soil Area

Chengshi guidao jiaotong yanjiu
Objective Metro shield construction in soft soil areas inevitably disturbs surrounding soil mass，threatening the safety of surrounding buildings and structures in severe cases.
Huilai QIN, Desheng WEI, Lei ZHAI, Zheng CHEN, Xilin LYU, Hongguo DIAO, Yuxuan ZHU   +6 more
doaj   +1 more source

The Control of Shield Tunnel Construction-Induced Ground Settlement Based on an Optimized Gap Parameter Theory and Three-Dimensional Finite Element Analysis

Buildings
The ground settlement induced by shield tunnel construction should be carefully monitored and controlled during construction as a compulsory measurement to ensure construction safety. In the existing literature, gap parameter theory is adopted to predict
Hanzhang Guo, Guangcheng Zhang, Zhihong Wu, Jiaqi Wang   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Theoretical Calculation Method of Ground Settlement Based on a Groundwater Seepage and Drainage Model in Tunnel Engineering

Sustainability, 2021
Seepage is ubiquitous during tunneling in areas with high groundwater tables. The ground settlement trough on a single tunnel is well described by Peck’s formula, but it cannot reflect the settlement caused by seepage.
Zheng Wei, Yan-Peng Zhu
semanticscholar   +1 more source

Research on Deformation Patterns and Influencing Factors of Ten Pilot Tunnel Pile Method Construction in Large Span Metro Stations

Chengshi guidao jiaotong yanjiu
［Objective］ To ensure the construction safety of large span metro stations, it is necessary to conduct research on the deformation patterns of the station structure and the influencing factors in the construction process of ten pilot tunnel pile method. ［
ZHOU Tao
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Analysis of Ground Settlement Caused by Double-line TBM Tunnelling Under Existing Building

Geotechnical and Geological Engineering, 2021
TBM tunnelling is less used in the subway construction in prosperous city due to the limitation of the engineering geological conditions. The studies on the influence of the TBM construction on the existing buildings are also limited. Therefore, based on
Dong Hao, Ren-Jun Zhu, Ke Wu, Rong Chen
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source