Results 111 to 120 of about 4,330,694 (342)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A K‐band eight‐element reconfigurable phased‐array receiver with high Tx‐band rejection

open access: yesIET Microwaves, Antennas & Propagation
A K‐band eight‐element phased‐array receiver is proposed, featuring a reconfigurable beam count and high Tx‐band rejection, tailored for satellite communication applications. By precisely designing the inter‐stage and output matching networks of the four‐
Zhuoheng Xie   +10 more
doaj   +1 more source

Spin-3/2 Ising model on a two-layer Bethe lattice with FM/AFM interactions

open access: yesCondensed Matter Physics, 2009
Two-layer Bethe lattice whose lattice sites are occupied with spin-3/2 atoms is solved exactly by using the recursion relations in a pairwise approach for given coordination numbers q=3,4 and 6 with equal external magnetic fields acting on the layers ...
E. Albayrak, A. Yigit
doaj   +1 more source

Application of open-source software for industrial problems of vehicle lift-off gas dynamics

open access: yesВестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017
High-power shock, heat, mechanical and especially acoustic loads present a serious problem as their impact on the rocket and the launch pad can be too strong. Turbulent supersonic jets ejected from the vehicle nozzles are the main source of these loads.
T. O. Abdurashidov   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

All-optical polarization-filtered subwavelength imaging in microwave regime via atom-based polarization holography

open access: yesCommunications Physics
Polarization imaging is essential to reveal rich information of the vectorial nature of microwaves. However, selective imaging of specific polarization components with subwavelength resolution remains challenging. Here, we propose atom-based polarization
Ziyao Lyu   +4 more
doaj   +1 more source

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