Results 111 to 120 of about 4,316,417 (322)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Construction and analysis of numerical algorithms for Erdelyi–Kober fractional integral equations

open access: yesScientific African
Erdelyi–Kober fractional integral (EKI) operator is a generalization of Riemann–Liouville integral (RLI) and has applications in diverse areas. However, unlike the RLI whose singular kernel is linear in the integration variable, the singular kernel of ...
Chinedu Nwaigwe, Abdon Atangana
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Normalized Ground States for Mixed Fractional Schrödinger Equations with Combined Local and Nonlocal Nonlinearities

open access: yesFractal and Fractional
This paper studies the existence, regularity, and properties of normalized ground state solutions for the mixed fractional Schrödinger equations. For subcritical cases, we establish the boundedness and Sobolev regularity of solutions, derive Pohozaev ...
Jie Yang, Haibo Chen
doaj   +1 more source

Home - About - Disclaimer - Privacy