Results 61 to 70 of about 248,226 (264)
Ground state solutions for a nonlinear Choquard equation
, 2016 We discuss the existence of ground state solutions for the Choquard equation $$-Δu=(I_α*F(u))F'(u)\quad\quad\quad\text{in }\mathbb R^N.$$ We prove the existence of solutions under general hypotheses, investigating in particular the case of a homogeneous nonlinearity $F(u)=\frac{|u|^p}p$. The cases $N=2$ and $N\ge3$ are treated differently in some steps.
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
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Existence and multiplicity results for a coupled system of Kirchhoff type equations
Electronic Journal of Qualitative Theory of Differential Equations, 2014 This paper deals with a coupled system of Kirchhoff type equations in ${\mathbb{R}}^{3}$. Under suitable assumptions on the potential functions $V(x)$ and $W(x)$, we obtain the existence and multiplicity of nontrivial solutions when the parameter ...
Dengfeng Lü, Jianhai Xiao
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Numerical method for the ground state solution of Logarithmic nonlinear Schrodinger equation
四川大学学报. 自然科学版, 2021 We construct a numerical method for computing the ground state solution of Logarithmic nonlinear Schrodinger equation. We firstly regularize the energy functional of the model and then compute the ground state solution by using the normalized gradient ...
FENG Zi-Xu, HE Wei-Qing, ZHANG Shi-Quan
doaj
Ground state solution of a noncooperative elliptic system [PDF]
Differential Equations & Applications, 2013 9 ...
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
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