Results 81 to 90 of about 249,335 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Existence of a ground-state solution for a quasilinear Schrödinger system

Frontiers in Physics
In this paper, we consider the following quasilinear Schrödinger system.−Δu+u+k2Δ|u|2u=2αα+β|u|α−2u|v|β,x∈RN,−Δv+v+k2Δ|v|2v=2βα+β|u|α|v|β−2v,x∈RN,where k < 0 is a real constant, α > 1, β > 1, and α + β < 2*.
Xue Zhang, Jing Zhang, Jing Zhang, Jing Zhang   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Existence of positive ground state solutions for a class of asymptotically periodic Schrodinger-Poisson systems

Electronic Journal of Differential Equations, 2017
In this article, by using variational method, we study the existence of a positive ground state solution for the Schr\"odinger-Poisson system $$\displaylines{ -\Delta u+V(x)u+K(x)\phi u=f(x,u),\quad x\in\mathbb{R}^3,\cr -\Delta\phi=K(x)u^2,\quad x\in\
Da-Bin Wang, Hua-Fei Xie, Wen Guan
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multiple solutions for a fractional $(p,t)$-Laplacian system with logarithmic nonlinearities

Electronic Journal of Qualitative Theory of Differential Equations
This paper is concerned with the existence and multiplicity of a ground state solution for a class of fractional $(p,t)$-type systems involving logarithmic nonlinearities with sign-changing coefficients, which are obtained by variational methods.
Romulo Carlos, Victor Carvalho de Oliveira, Olimpio Miyagaki   +2 more
doaj   +1 more source

Existence of Positive Ground State Solution for the Nonlinear Schrödinger-Poisson System with Potentials

Advances in Mathematical Physics, 2018
In the present paper we study the existence of positive ground state solutions for the nonautonomous Schrödinger-Poisson system with competing potentials. Under some assumptions for the potentials we prove the existence of positive ground state solution.
Lu Xiao, Haiqin Qian, Mengmeng Qu, Jun Wang   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source