Results 71 to 80 of about 292,062 (325)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Application of wavelet analysis in tool wear evaluation using image processing method

, 2018
Tool wear plays a significant role for proper planning and control of machining parameters to maintain the product quality. However, existing tool wear monitoring methods using sensor signals still have limitations.
Sia, Chee Kiong, Tuan Muda, Syed Mohamad Aiman, Ong, Pauline, Talib, Norfazillah, Saleh, Aslinda, Lee, Woon Kiow   +5 more
core   +1 more source

Influence of Subway Shield Tunnel Construction on Ground Settlement

, 2021
Shield construction has the advantages of stable driving speed, saving manpower, and being able to carry out construction in complex strata, which has been more and more widely used.
Dan Cheng, Wenxiao Li, Yilei Zhang, Jianxun Ma   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ground water and surface water under stress [PDF]

, 2006
Presented at Ground water and surface water under stress: competition, interaction, solutions: a USCID water management conference on October 25-28, 2006 in Boise, Idaho.The Gila River water rights settlement will restore to the Gila River Indian ...
Keller, Andy A., author, Flynn, Tim, author, Bannister, Peter S., author, Flynn, Timothy J., author, Westfall, Brian D., author, Lindstrom, Shane, author, Keller, Andrew A., author, Bliesner, Ronald D., author, U.S. Committee on Irrigation and Drainage, publisher   +8 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Investigation of surface settlement of ground caused by cut-and-cover tunneling in Urmia Interchange

, 2020
Earth's surface settlement is one of the most important tunnel drilling circumstances that has been studied by many international investigations to control its effects. This paper investigates the effect of cut-and-cover tunnel construction at the ground
Chiya Gharakhan
core   +1 more source

Carboxylic‐Acid Functionalized Multiwalled Carbon Nanotube‐Alkane‐Based Resistive Temperature Sensor for Cold Chain Applications

Advanced Engineering Materials, EarlyView.
This study presents a reversible temperature sensor with high switching ratio, ∼103. The device is fabricated using PET‐ITO and carbon nanotube dispersions in alkane. Considering its application in cold chain logistics, a proof‐of‐concept with LED is showcased. Thus, a temperature drop below the threshold temperature (crystallization temperature of the
Sunil Kumar Behera, Philippe Marrec, A. Jorge Parola, Madalena Dionísio, Hugo Águas, Andreia F. M. Santos, Hamed Pourkheirollah, Donald Lupo, César A. T. Laia   +8 more
wiley   +1 more source

Pecos River Carlsbad Settlement agreement [PDF]

, 2006
Presented at Ground water and surface water under stress: competition, interaction, solutions: a USCID water management conference on October 25-28, 2006 in Boise, Idaho.The Pecos River Decision Support System (PRDSS) is a complex set of hydrologic ...
Barroll, Peggy, author, McCord, Jim, author, Elhassan, Ali, author, Carron, John, author, U.S. Committee on Irrigation and Drainage, publisher   +4 more
core