Results 71 to 80 of about 6,384,714 (292)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Effect of Lubricant Young’s Modulus on Surface Settlement Control During Pipe-Roof Construction Using Pipe-Jacking Method

Applied Sciences
During pipe-roof construction using pipe-jacking technology, lubricants are injected into the tail void to reduce pipe–soil friction and minimize soil loss. However, research on ground settlement caused by multiple adjacent pipe jackings remains limited,
Shuai Zhang, Takashi Sasaoka, Akihiro Hamanaka, Xiaohu Hu, Peng Ma, Hideki Shimada   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Settlement early warning method for high speed railway subgrades based on TD Transformer

Scientific Reports
During high speed railway construction, shield-tunnel undercrossing frequently induces subgrade settlement, which threatens project safety and progress. Existing settlement monitoring methods struggle to provide timely early warnings due to unclear data ...
Wen Kebing, Liang Qinghuai
doaj   +1 more source

Ground-Surface Settlement Control and Prediction for Twin Tunnels Excavated Above an Existing Tunnel: Effects of Existing-Tunnel Constraint

Applied Sciences
As urban rail transit networks become denser, twin tunnels are increasingly constructed in close proximity above existing operational tunnels, making ground surface settlement control and existing tunnel protection critical challenges.
Jian Lu, Yanlin Li, Ning Jia, Panyi Wei, Chunyang Li, Yongyan Yu, Aijun Yao   +6 more
doaj   +1 more source

Surface settlement modelling using neural network 1

, 2021
Ground movement control during tunnelling in urban areas has always been a key concern, as geotechnical engineers strive to minimize any disturbance to nearby buildings and services. Previous studies concerning surface settlement were conducted based on
Tan, Jerie-Ann
core  

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Prediction of ground surface settlements by analytical and finite element methods

IOP Conference Series: Earth and Environmental Science
Abstract The soil surrounding the excavation of shallow tunnels may experience destructive deformation near the tunnels. Particularly in densely populated areas where land resources are scarce, ground subsidence caused by tunnel excavation, which in turn affects surrounding structures, deserves more attention.
Y H Wang, C C Lam, M H Lok
openaire   +1 more source

Cryogenic Deformation Behavior of TiAl and Insights Into Embrittlement After High‐Temperature Exposure Combined With Secondary Ion Mass Spectroscopy of Near Surface Chemistry

Advanced Engineering Materials, EarlyView.
Near‐surface deuterium enrichment profiles for different microstructural types of TiAl after exposure at 700 °C in a heavy water‐containing environment. The deuterium levels are significantly higher than expected from natural occurrence, indicating that the heavy water dissociated during the exposure treatment and entered the specimens.
Jonathan D. H. Paul, Alexander Welle, Dirk Matthiessen, Michael Oehring, Fritz Appel, Florian Pyczak   +5 more
wiley   +1 more source