Results 31 to 40 of about 465,759 (266)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Water quality assessment of the Tano Basin in Ghana: a multivariate statistical approach

Applied Water Science, 2021
Multivariate statistical techniques including principal component and factor analyses were applied in this study to assess the quality of surface water from Tano basin in Ghana.
Samuel Obiri, Gloria Addico, Saada Mohammed, Wilson William Anku, Humphry Darko, Okrah Collins   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Isolation of bacterial pathogens from chicken manure, eggshell, and sediments in Changchun City reveal high multidrug-resistant, indices of multiple antibiotic resistance, virulence determinants, and genetic variation.

The Microbe
Pathogens have exhibited the potential for acquiring multiple antibiotic resistance, including beta-lactams, carbapenems and fluoroquinolones. Understanding the transmission dynamics, antimicrobial resistance profile and genetic diversity of the ...
Abdul Razak Alhassan, Xinran Lin, Guangze Lyu, Jiawen Lu, Courage Kosi Setsoafia Saba, Jincai Ma   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A case study on predicting groundwater quality in a drought-prone region of Vidarbha, Maharashtra using machine learning models

Applied Water Science
Groundwater is key to ecosystem health, food production and interlinked hydrological processes in dryland regions under a changing climate, therefore assessment of groundwater quality becomes imperative.
Bhumika Kumari, Pandith Madhnure, Rakesh Dewangan, Umesh Balpande, Annadasankar Roy, Kondayya Gundra, Abhijit Mukherjee, Tirumalesh Keesari   +7 more
doaj   +1 more source

Sustainability of groundwater through community-driven distributed recharge: An analysis of arguments for water scarce regions of semi-arid India

Journal of Hydrology: Regional Studies, 2020
Study Region: Semi-Arid Regions of Marathawada, Vidarbha and Saurashtra in IndiaStudy Focus: To understand and evaluate the impact of Managed Aquifer Recharge (MAR) efforts.New Hydrological Insights for the Region: Since 1990, the Saurashtra region of ...
Praharsh M. Patel, Dipankar Saha, Tushaar Shah   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source