Results 31 to 40 of about 485,769 (266)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Geophysical insights into aquifer characteristics of the Tanakpur area in Champawat district, Uttarakhand, India

Discover Geoscience
Proper demarcation of aquifers in hard rock areas is a challenging task, and geophysical surveys have been effective in deciphering the aquifers. Vertical Electrical Soundings (VES) were carried out in the Tanakpur area of Champawat district, Uttarakhand
Somvir Singh
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Isolation of bacterial pathogens from chicken manure, eggshell, and sediments in Changchun City reveal high multidrug-resistant, indices of multiple antibiotic resistance, virulence determinants, and genetic variation.

The Microbe
Pathogens have exhibited the potential for acquiring multiple antibiotic resistance, including beta-lactams, carbapenems and fluoroquinolones. Understanding the transmission dynamics, antimicrobial resistance profile and genetic diversity of the ...
Abdul Razak Alhassan, Xinran Lin, Guangze Lyu, Jiawen Lu, Courage Kosi Setsoafia Saba, Jincai Ma   +5 more
doaj   +1 more source

Determination of silt thickness in Durga Kund for its de-isolation at Varanasi U.P. India

Water Science, 2020
In this study, we are focused on the re-connection of Kund to the water table. Kunds are the best ancient architectural construction that was connected to the underground water table and works upon the principle of the Capillary action.
Daya Shankar Singh, Rakesh Singh, Ajai Mishra   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A case study on predicting groundwater quality in a drought-prone region of Vidarbha, Maharashtra using machine learning models

Applied Water Science
Groundwater is key to ecosystem health, food production and interlinked hydrological processes in dryland regions under a changing climate, therefore assessment of groundwater quality becomes imperative.
Bhumika Kumari, Pandith Madhnure, Rakesh Dewangan, Umesh Balpande, Annadasankar Roy, Kondayya Gundra, Abhijit Mukherjee, Tirumalesh Keesari   +7 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source