Results 31 to 40 of about 467,505 (266)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Geophysical insights into aquifer characteristics of the Tanakpur area in Champawat district, Uttarakhand, India

Discover Geoscience
Proper demarcation of aquifers in hard rock areas is a challenging task, and geophysical surveys have been effective in deciphering the aquifers. Vertical Electrical Soundings (VES) were carried out in the Tanakpur area of Champawat district, Uttarakhand
Somvir Singh
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Determination of silt thickness in Durga Kund for its de-isolation at Varanasi U.P. India

Water Science, 2020
In this study, we are focused on the re-connection of Kund to the water table. Kunds are the best ancient architectural construction that was connected to the underground water table and works upon the principle of the Capillary action.
Daya Shankar Singh, Rakesh Singh, Ajai Mishra   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Isolation of bacterial pathogens from chicken manure, eggshell, and sediments in Changchun City reveal high multidrug-resistant, indices of multiple antibiotic resistance, virulence determinants, and genetic variation.

The Microbe
Pathogens have exhibited the potential for acquiring multiple antibiotic resistance, including beta-lactams, carbapenems and fluoroquinolones. Understanding the transmission dynamics, antimicrobial resistance profile and genetic diversity of the ...
Abdul Razak Alhassan, Xinran Lin, Guangze Lyu, Jiawen Lu, Courage Kosi Setsoafia Saba, Jincai Ma   +5 more
doaj   +1 more source

Water quality assessment of the Tano Basin in Ghana: a multivariate statistical approach

Applied Water Science, 2021
Multivariate statistical techniques including principal component and factor analyses were applied in this study to assess the quality of surface water from Tano basin in Ghana.
Samuel Obiri, Gloria Addico, Saada Mohammed, Wilson William Anku, Humphry Darko, Okrah Collins   +5 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

A case study on predicting groundwater quality in a drought-prone region of Vidarbha, Maharashtra using machine learning models

Applied Water Science
Groundwater is key to ecosystem health, food production and interlinked hydrological processes in dryland regions under a changing climate, therefore assessment of groundwater quality becomes imperative.
Bhumika Kumari, Pandith Madhnure, Rakesh Dewangan, Umesh Balpande, Annadasankar Roy, Kondayya Gundra, Abhijit Mukherjee, Tirumalesh Keesari   +7 more
doaj   +1 more source